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Agencourt DNAdvance, SOLiD conversion tool, LabChip GX, LabChip GXII, Clean Genome MDS42recAtrfA

Beckman Coulter has launched the Agencourt DNAdvance system, a kit for isolating and purifying mammalian DNA. It incorporates Agencourt’s Solid Phase Reversible Immobilization, or SPRI, paramagnetic bead-based nucleic acid-purification technology. The chemistry can be automated on the Beckman Coulter Biomek NXP and FXP workstations to process three 96-well plates in about 75 minutes without the use of organic solvents, vacuum filtration, or centrifugation, according to the company. Full automation can be achieved with a PlateStak automated microplate handler. Researchers at the Rutgers University Bionomics Research and Technology Center have been beta-testers of the kit. 

SoftGenetics has launched a tool that converts “color space” Fasta files generated by the ABI SOLiD system into “base space.” The SOLiD conversion tool allows researchers to use the company’s NextGENe software suite for de novo assembly, target assembly, SNP and indel detection, transcriptome analyses, and other analyses of SOLiD data. According to the company, the tool “simultaneously operates in two dimensions — color space and base space — comparing and correcting obvious errors to maximize the inherent accuracy of the SOLiD system.” Customers can request a free 30-day evaluation of the tool.

Caliper Life Sciences has launched LabChip GX and LabChip GXII benchtop systems for fast and automated 1-D electrophoretic separation of proteins, DNA, and RNA. LabChip GX is an entry system targeted at genomics applications, while the GXII, a replacement of the LabChip 90, combines both genomics and protein research applications. The LabChip GX instrument can be used to analyze RNA integrity for better RT-PCR and microarray gene expression data, to analyze DNA fragments for sequencing applications, to genotype transgenic mice, and other applications.

Scarab Genomics has launched Clean Genome MDS42recAtrfA E. coli, a competent cell line with multiple gene deletions. The strain misses the recA gene, increasing the stability of the MDS42 genome and plasmids introduced into it. Using a tightly regulated promoter controlling the trfA gene, plasmid replication can be controlled within the cell, giving researchers more control over plasmid copy number. The cells also lack insertion sequence elements, increasing clone stability.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.