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This story has been updated to include additional comments from Encarnita Mariotti-Ferrandiz.

NEW YORK – Immune cell profiling products offered by Adaptive Biotechnologies and Takara Bio ranked high in measures of reproducibility, reliability, and sensitivity in a new benchmarking study that compared nine different T cell receptor (TCR) sequencing methods. But the head-to-head comparison revealed "large systemic biases," the study authors said, with respect to the T cell clonotypes the methods uncovered.

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