Skip to main content
Premium Trial:

Request an Annual Quote

ABI Says SOLiD 3 Run Yielded 50 Gb Human Sequence Data As Part of Disease Study with Baylor's HGSC


Applied Biosystems said today that company researchers have generated 50 gigabases of human genome sequence data, or 17-fold average coverage of the genome, in a single run on the SOLiD 3 sequencer.

The mate-pair data was generated as part of a research project with Baylor College of Medicine's Human Genome Sequencing Center, which provided the sample, taken from an individual with an unspecified genetic disorder.

As part of a second project with the HGSC, ABI researchers generated 30 gigabases of data, or 10-fold coverage, in a SOLiD run from a human brain cancer sample.

The SOLiD system used in these projects was equipped with new bead-finding and quantitation genomic analysis software, ABI said.

A company spokesperson said that David Wheeler, an associate professor of molecular and human genetics and a member of the HGSC, is scheduled to present data from these projects at the annual Biology of Genomes meeting at Cold Spring Harbor Laboratory later today.

According to ABI, the HGSC is currently equipped with 10 SOLiD systems, which are used in a variety of human disease research projects, including cancer and genetic disorders.

A year ago, the HGSC said it was acquiring six SOLiD instruments that it was planning to use to generate data for the 1,000 Genomes Project (see In Sequence 4/29/2008).

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.