As second-generation sequencers from Roche/454, Illumina, and Life Technologies compete for targeted sequencing market share, researchers at the Scripps Research Institute and the J. Craig Venter Institute recently published an evaluation of the three platforms for this application.

The two teams, which used versions of the platforms that have since been updated, found they each suffered from non-uniform coverage and inherent systematic errors, making it difficult to use data from different platforms for the same study.

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