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10x Genomics, PerkinElmer Collaborate to Automate Sequencing Workflow

NEW YORK (GenomeWeb) – 10x Genomics and PerkinElmer said today that they have partnered to develop a workflow that combines PerkinElmer's automation technology with 10x Genomics' linked-reads for exome and whole-genome sequencing.

The two firms said that the workflow will enable large-scale studies from samples like saliva and archived dried blood spots. The collaboration combines PerkinElmer's Chemagic nucleic acid extraction technology and Sciclone automation platform with the 10x Genomics' Chromium instrument, and enables sequencing to be done from as little as 1 nanogram of input DNA.

"Long-range information is necessary to get a comprehensive view of variants in the genome, and our collaboration with 10x provides contextual genomic and haplotype information from [dried blood spot] samples, thereby providing increased resolution to variant calling, especially in regions of the genome inaccessible by short-reads," PerkinElmer Laboratory Services Vice President and CSO Madhuri Hegde said in a statement. She added that PerkinElmer planned to use the combined workflow in its whole-genome and -exome sequencing services.

Anjana Narayanan, product manager at 10x Genomics, added that the collaboration would enable population genomics studies with "a cost-effective, high throughput method to interrogate archival samples that are otherwise inaccessible." The workflow will "better serve our customers and meet the clinical research community's critical need for long-range information from difficult but standard samples types like dried blood spots," Narayanan added.

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