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NEW YORK (GenomeWeb) – Two independent research teams have developed computational methods for spatially mapping individual cells profiled by single-cell RNA sequencing back to their original positions using marker genes measured separately with in situ techniques.

The approaches, described in studies published online this week in Nature Biotechnology, involve integrating information about genes that are co-expressed in individual cells to match these cells up against reference maps with information on a far more limited number of marker genes.

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