Single Neuron Sequencing Reveals SNVs, Brain Cells' Diverse Lineage

Oct 01, 2015

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NEW YORK (GenomeWeb) – Researchers from Harvard University have sequenced the whole genomes of single neurons in a proof-of-concept study to understand the somatic mutation process in brain cells.

Reporting their work today in Science, the researchers sequenced whole genomes of 36 single neurons from the cerebral cortexes of three healthy individuals. They identified thousands of SNVs and were able to piece together the cells' lineage.

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