Single Neuron Sequencing Reveals SNVs, Brain Cells' Diverse Lineage

Oct 01, 2015

|

NEW YORK (GenomeWeb) – Researchers from Harvard University have sequenced the whole genomes of single neurons in a proof-of-concept study to understand the somatic mutation process in brain cells.

Reporting their work today in Science, the researchers sequenced whole genomes of 36 single neurons from the cerebral cortexes of three healthy individuals. They identified thousands of SNVs and were able to piece together the cells' lineage.

To read the full story....

...and receive Daily News bulletins.

Already have a GenomeWeb or 360Dx account?
Login Now.

Don't have a GenomeWeb or 360Dx account?
Register for Free.

Breaking News

The Scan

Search Decisions

The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

The Mouse of the Situation

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

Pain Targeted

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

Science Presents Malaria Cell Atlas, More

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.

Featured White Papers

A High-Performance Solution Combining CleanPlex OncoZoom Cancer Hotspot Panel and SOPHiA AI for Rapid Characterization of Somatic Mutations

Automated Genomic DNA Extraction from Large Volume Whole Blood

Automated Library Preparation for the MCI Advantage Cancer Panel Utilizing the Beckman Coulter Biomek i5 Span-8 NGS Workstation

Correlation Between Mutations Found in FFPE Tumor Tissue and Paired cfDNA Samples

Aug

29

Featured Webinar

Biobanking at Scale to Support Precision Medicine

This webinar will outline how RUCDR Infinite Biologics, the world's largest university-based biorepository, has implemented workflows and processes to support precision medicine applications.

Sep

18

Featured Webinar

Highly Sensitive Structural Variant Detection for Medical Genetics: A Comparison to the Standard of Care

This webinar will outline how a team at Radboud University Medical Center is assessing ultra-long read optical mapping on the Bionano Saphyr system to replace classical cytogenetics approaches in routine testing and for the discovery of novel structural variants with potential scientific, prognostic, or therapeutic value that are missed by standard approaches.

Oct

01

Featured Webinar

Future-Proofing a Genomics Core: Considerations When Adopting New NGS Technologies

This webinar will provide an overview of the sequencing capabilities of the Tumor Profiling Unit at the Institute for Cancer Research in London, with a focus on the lab's strategy for bringing in new genomics technologies.

Oct

03

Featured Webinar

Streamlined and High-Precision Cancer Analysis Using an Automated NGS Workflow in the Reference Lab Setting

This webinar will provide an overview of how an international reference laboratory has implemented an automated next-generation sequencing workflow with custom panels for analyzing cancer samples.

Menu