Ovarian Cancer Biomarker Search Uncovers Low-Frequency TP53 Mutations in Healthy Individuals | GenomeWeb

NEW YORK (GenomeWeb) – Somatic mutations in the cancer-related gene TP53 turn up at very low levels in peritoneal fluid from healthy individuals, becoming more prevalent in women with ovarian cancer, according to a study published this week in the Proceedings of the National Academy of Sciences.

Researchers from the University of Washington used a sensitive method called duplex sequencing to search for low-frequency TP53 gene mutations in peritoneal fluid samples from 17 women with high-grade serous ovarian cancer (HGSOC) and 20 women without.

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