variants of unknown significance

All the Uncertainty

Variants of unknown significance don't give patients the answers they are seeking, the Guardian writes.

One paper involving experts from Myriad Genetics and another from Invitae added fresh data to a contentious debate over the use of public variant databases.

In Williams v Quest/Athena, a federal district court judge has asked the highest state court to clarify if a genetic testing lab is a licensed healthcare provider.

This Week in PLOS

In PLOS this week: analysis of viral sequences from human blood samples, gut microbiomes of heart failure patients, and more.

Judge Margaret Seymour held a hearing to better understand the facts of the case before deciding whether it should go forward.

In a new AMP working group project, labs can volunteer to compare their interpretation of challenging variants to help identify where and how the guidelines might be improved.

Experts pointed out the lack of clarity in professional standards and regulations when it comes to dealing with genetic variation in patient care. 

A high-profile, independent committee is considering the liability issues impacting labs as genetic testing increasingly becomes integrated into patient care.

The database is intended to provide the research community with a resource of control cases to aid in the evaluation of variants of unknown significance in breast cancer.

Multiple variant databases are creating competition among groups that disagree on how to advance the most scientifically robust and sustainable sharing model.

Pages

The ancestors of the Arizona bark scorpion and other scorpions and spiders underwent whole-genome duplication, KJZZ reports.

A cryptographic approach could help researchers keep genomic data private while researchers analyze it, Scientific American reports.

Andy Page, the former president of 23andMe, has joined a diabetes-management startup, according to CNBC.

In Cell this week: regulatory changes in pancreatic cancer, metabolic shifts in Alzheimer's disease, and more.