tumor mutational burden BostonGene Closes $150M Series B Funding Round The firm will use the financing to further the development, clinical expansion, and international availability of its Tumor Portrait tests. Illumina Obtains CE-IVD Marking for European Version of TSO Comprehensive Assay The next-generation sequencing-based assay detects variants in 517 genes and genomic signatures using formalin-fixed, paraffin-embedded tumor tissue samples. Genomes of Advanced Neuroendocrine Neoplasms Unveil Subtypes, Treatment Clues By sequencing dozens of locally advanced or metastatic neuroendocrine neoplasm samples, researchers detected somatic mutations that varied with primary tumor site and subtype. MSK Study Underscores Need to Validate Cancer-Specific Tumor Mutational Burden Cutoffs Premium A TMB-high cutoff of 10 mutations per megabase doesn't predict immunotherapy responses universally well across cancer types, according to a paper published in JAMA Oncology. Diagnostics Firms, Lab Providers Form Genomic Profiling Coalition The new consortium is aiming to make comprehensive genomic profiling accessible to advanced cancer patients in the US, to help inform their treatment decisions. Nov 9, 2020 FDA Approves Foundation Medicine Liquid Biopsy Test as CDx for Lynparza Oct 7, 2020 Immunotherapy Response Prediction Improved by Baseline, On-Treatment Biomarker Combo Premium Sep 23, 2020 Multi-Biomarker Strategies Show Promise in Improving Immunotherapy Response Prediction Premium Jul 24, 2020 TMB Harmonization Effort Yields Calibration Method to Correct Inter-Assay Variation Premium Jul 21, 2020 NCCN's Updated Inherited Colorectal Cancer Risk Guidelines Features Gene-Specific Information Jun 22, 2020 Genomic Study Reveals Recurrent Cutaneous Melanoma Alterations, Male-Specific Mutations Jun 17, 2020 FDA Approves Merck's Keytruda, Foundation Medicine CDx for TMB-High Solid Tumors Jun 4, 2020 Tumor Mutational Burden in Blood May Predict Immunotherapy Response in Head, Neck Cancer Apr 30, 2020 TMB Harmonization Data Extends Concordance Findings, Tests Calibration Methods Apr 15, 2020 Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests Apr 14, 2020 Merck Bid for Second Pan-Cancer Keytruda Indication Would Raise Tumor Mutation Burden to CDx Status Premium Apr 13, 2020 Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome Mar 25, 2020 Prostate Cancer Cases in China Show Recurrent Alterations Distinct From Western Cohorts Feb 12, 2020 Exact Sciences Boosting Position in Cancer Dx Market Through M&A Premium Feb 5, 2020 Large-Scale Pan-Cancer Analysis Expands Set of Alterations Disrupting Key Genes, Pathways Jan 14, 2020 Immunotherapy Response Prediction Improves With TMB Correction, Other Markers Premium Dec 18, 2019 DNAnexus PrecisionFDA Platform Expansion Will Add Support for Multi-Omics Data, Interactive Review Premium Dec 17, 2019 NeoGenomics Focused on Companion Diagnostics, NGS in 2020 Premium Nov 19, 2019 Despite FDA Clearance for NantHealth Test, Benefits of TMB Biomarker Unclear Premium Nov 19, 2019 Paragon Genomics Discusses New Gene Fusion Detection Method, Cystic Fibrosis Panel Premium Load More Breaking News Single-Nucleus Chromatin Accessibility Profiling in Coronary Artery Disease Points to Mechanisms ALL Genomes Marked by High DNA Methylation Levels Cepheid Gets CE Mark for Updated Rapid COVID MDx Test Mainz Biomed, Dante Labs Partner to Commercialize ColoAlert in Europe, UAE CellCarta Acquires Rights to Targeted Protein Assays from Fred Hutch Spinout Precision Assays Genetic Analysis, Omnigene Medical Technologies Ink Distribution, Tech Transfer Deal The Scan Monkeypox Case Found in US The New York Times says that a case of monkeypox has now been reported in the US. Effects on Fetal Screening Wired writes that changes to US abortion laws could affect screening for fatal congenital conditions. 'Pharma Bro' Out of Prison The Wall Street Journal reports that Martin Shkreli has been released from prison to a halfway house. Nature Papers Present Cultivate Oat Genome, Benchmarking of Spatial and Single-Cell Transcriptomic Integration Methods In Nature this week: reference genome of the cultivated oat, and more.