tumor mutational burden Genomes of Advanced Neuroendocrine Neoplasms Unveil Subtypes, Treatment Clues By sequencing dozens of locally advanced or metastatic neuroendocrine neoplasm samples, researchers detected somatic mutations that varied with primary tumor site and subtype. MSK Study Underscores Need to Validate Cancer-Specific Tumor Mutational Burden Cutoffs Premium A TMB-high cutoff of 10 mutations per megabase doesn't predict immunotherapy responses universally well across cancer types, according to a paper published in JAMA Oncology. Diagnostics Firms, Lab Providers Form Genomic Profiling Coalition The new consortium is aiming to make comprehensive genomic profiling accessible to advanced cancer patients in the US, to help inform their treatment decisions. FDA Approves Foundation Medicine Liquid Biopsy Test as CDx for Lynparza The test will use a blood-based biopsy to detect patients with BRCA1, BRCA2, and/or ATM alterations in metastatic castration-resistant prostate cancer. Immunotherapy Response Prediction Improved by Baseline, On-Treatment Biomarker Combo Premium Stanford and Memorial Sloan Kettering researchers have developed a multi-modal and multi-timepoint biomarker approach to predict therapeutic benefit in lung cancer cases. Sep 23, 2020 Multi-Biomarker Strategies Show Promise in Improving Immunotherapy Response Prediction Premium Jul 24, 2020 TMB Harmonization Effort Yields Calibration Method to Correct Inter-Assay Variation Premium Jul 21, 2020 NCCN's Updated Inherited Colorectal Cancer Risk Guidelines Features Gene-Specific Information Jun 22, 2020 Genomic Study Reveals Recurrent Cutaneous Melanoma Alterations, Male-Specific Mutations Jun 17, 2020 FDA Approves Merck's Keytruda, Foundation Medicine CDx for TMB-High Solid Tumors Jun 4, 2020 Tumor Mutational Burden in Blood May Predict Immunotherapy Response in Head, Neck Cancer Apr 30, 2020 TMB Harmonization Data Extends Concordance Findings, Tests Calibration Methods Apr 15, 2020 Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests Apr 14, 2020 Merck Bid for Second Pan-Cancer Keytruda Indication Would Raise Tumor Mutation Burden to CDx Status Premium Apr 13, 2020 Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome Mar 25, 2020 Prostate Cancer Cases in China Show Recurrent Alterations Distinct From Western Cohorts Feb 12, 2020 Exact Sciences Boosting Position in Cancer Dx Market Through M&A Premium Feb 5, 2020 Large-Scale Pan-Cancer Analysis Expands Set of Alterations Disrupting Key Genes, Pathways Jan 14, 2020 Immunotherapy Response Prediction Improves With TMB Correction, Other Markers Premium Dec 18, 2019 DNAnexus PrecisionFDA Platform Expansion Will Add Support for Multi-Omics Data, Interactive Review Premium Dec 17, 2019 NeoGenomics Focused on Companion Diagnostics, NGS in 2020 Premium Nov 19, 2019 Despite FDA Clearance for NantHealth Test, Benefits of TMB Biomarker Unclear Premium Nov 19, 2019 Paragon Genomics Discusses New Gene Fusion Detection Method, Cystic Fibrosis Panel Premium Nov 12, 2019 AMP Attendees Reflect on Uptake of Tumor Mutational Burden Amid Validation, Utility Questions Premium Sep 23, 2019 PGDx Shares New MSI Data, Provides Update on FDA Bid for Pan-Cancer IVDs Premium Load More Breaking News SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes People in the News: New Appointments at Myriad Genetics, Becton Dickinson, Delfi Diagnostics, More In Brief This Week: Virginia Commonwealth University, Dovetail Genomics, Lucid Diagnostics, and More New Products Posted to GenomeWeb: Bio-Rad, PerkinElmer, Ares Genetics, Purigen Biosystems, More Genetron Health, Fosun Ink Commercialization Deal for Seq-MRD Test in China MultiMuTHER Team Tracks Expression, Metabolite Relationships in Aging TwinsUK Participants The Scan More Boosters for US Following US Food and Drug Administration authorization, the Centers for Disease Control and Prevention has endorsed booster doses of the Moderna and Johnson & Johnson SARS-CoV-2 vaccines, the Washington Post writes. From a Pig A genetically modified pig kidney was transplanted into a human without triggering an immune response, Reuters reports. For Privacy's Sake Wired reports that more US states are passing genetic privacy laws. Science Paper on How Poaching Drove Evolution in African Elephants In Science this week: poaching has led to the rapid evolution of tuskless African elephants.