tumor mutational burden
Association for Molecular Pathology Releases New Tumor Mutational Burden Testing Recommendations
The joint consensus guideline, authored by AMP, ASCO, CAP, and SITC, seeks to establish evidence-based standards for validation and reporting of TMB tests in the clinic.
Neoantigen Detection Platform Picks up T-Cell Responses to Tumor Mutations
Researchers combined tumor sequence, transcriptome, and patient immune cell response clues in their tumor-specific neoantigen detection and validation platform.
A comparison for 144 solid tumor samples showed a "high degree of alignment" with FoundationOne CDx and better calling of CNAs than Illumina's TSO 500.
Large Study of Early-Onset Colorectal Cancer Patients IDs Unique, Potentially Actionable Mutations
In younger patients, HER2 mutations were more prevalent in those who had MSI-high/TMB-high tumors, while POLE mutations were more common in MSS/TMB-high tumors, researchers reported at ASCO.
AACR Studies Flag Molecular Differences in Colorectal Cancer Patients of African, European Ancestry
Premium
Data presented at the meeting underscored the importance of studying diverse populations in order to improve equity in precision oncology.