tumor mutational burden
The company has derived and validated a mutational and gene expression score that predicts immunotherapy benefit across tumor types.
Studies Assess Tumor Aneuploidy to Guide Immunotherapy Treatment
Results from two new studies suggest that tumor aneuploidy can provide an additional layer of information to help predict response to checkpoint blockade immunotherapy.
Tumor-Only Sequencing Found to Overestimate Mutational Burden in Non-European Patients
After documenting excess TMB estimates in non-European cancer patients assessed by tumor-only sequencing, researchers came up with a calibration strategy to address the issue.
In new guidelines, an expert panel recommended IHC and PCR for certain cancer types and pointed out knowledge gaps supporting NGS in other settings.
NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling
The guidelines recognize the importance of molecular profiling in diagnosing, treating, and identifying clinical trial opportunities for children with high-grade gliomas.