TOMM40

The group demonstrated the ability of a genetic algorithm to gauge whether cognitively normal people are at risk of near-term mental decline.

The "opt-in" model ensures that customers are aware of the risks and limitations of this potentially sensitive data, but some are questioning whether the direct-to-consumer model is the appropriate mechanism for delivering information on APOE status, even with additional precautions.

Takeda will study the type 2 diabetes drug Actos as an Alzheimer's prevention treatment with the help of Zinfandel Pharmaceuticals' TOMM40 test to gauge which older adults at high risk of disease onset should be enrolled in clinical trials.

Takeda has taken an exclusive, worldwide license for the use of Zinfandel's TOMM40 assay as a biomarker for the risk of Alzheimer's disease in high-risk older adults with normal cognition.

Studies presented at an international conference this week suggest that TOMM40 genotyping could be a useful diagnostic strategy for predicting which healthy people with a family history of Alzheimer's will develop the disease early.

In a recent issue of The Pharmacogenomics Journal, a team led by Allen Roses, director of Duke University's Deane Drug Discovery Institute, published data from two independent study populations linking longer lengths of a polymorphic poly-T variant, rs10524523, with a higher risk of late-onset Alzheimer's disease. "This paper provides the data and the first opportunity for other research laboratories to test and validate the data," the study authors note.

The new Alzheimer's disease research foundation to be launched by Linda Avey will use 23andMe's research platform and its database of genetic risk association information to investigate the causes and discover new treatments for the disease.

Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.