TCGA

Researchers and clinicians attempting to select targeted therapies must take sample heterogeneity into account.

This Week in Nucleic Acids Research: Researchers describe a new method to find large-scale structural variants in cancer genomes, a glimpse at an approach for profiling miRNAs in tumor samples from TCGA, and more.

NEW YORK (GenomeWeb) – New thyroid cancer mutations reported recently by members of The Cancer Genome Atlas consortium are already finding their way into at least one sequencing-based genotyping test used to distinguish between benign thyroid nodules and thyroid malignancies.

NEW YORK (GenomeWeb) – A Maryland-based team used real-time, quantitative PCR to screen for human papillomavirus in blood and saliva in order to detect HPV-positive head and neck cancers, track their recurrence, and predict survival patterns.

NEW YORK (GenomeWeb) — An analysis of data from The Cancer Genome Atlas' comprehensive molecular profiling of squamous cell head and neck cancer has revealed a more complicated molecular landscape for the disease, and has identified a new genomic subset that indicates particularly poor survival.

NEW YORK (GenomeWeb) – An integrated molecular analysis of the stomach cancer gastric adenocarcinoma has prompted members of the Cancer Genome Atlas Research Network to put forth four molecular sub-types for the disease.

NEW YORK (GenomeWeb) – Members of the Cancer Genome Atlas today described driver mutations and potential drug targets detected in a common form of lung cancer called lung adenocarcinoma.

NEW YORK (GenomeWeb) — A study of RNA-seq data from several Cancer Genome Atlas cohorts has found that patterns of pseudogene expression correspond strongly with several molecularly or clinically defined cancer subtypes and, in some cases, might offer additional subtyping or prognostic prediction

NEW YORK (GenomeWeb News) – Genes involved in chromatin regulation are amongst those most prone to recurrent mutation in urothelial bladder cancer, according to a new Nature study from members of the Cancer Genome Atlas.

NEW YORK (GenomeWeb News) – A flurry of new studies is outlining findings from the first phase of an analysis that brings together Cancer Genome Atlas data on up to a dozen cancer types.

Pages

Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.