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secondary findings

ACMG Adds Five More Genes to Secondary Finding List

Pathogenic or likely pathogenic variants in the newly added genes contribute to risk of dilated cardiomyopathy or heart failure.

Secondary Genetic Findings Often Requested if Given Second Chance, Study Finds

The researchers said their findings support a switch to a model in which providing secondary findings is the default, with an opt-out mechanism.

ACMG Updates Gene List for Labs Reporting Clinical Sequencing Secondary Findings

The list, which ACMG plans to now update annually, currently includes 73 genes for which it recommends laboratories report findings.

ESHG, ACMG Differ Starkly in Recommendations for Reporting Secondary Findings From Genomic Tests
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During a session at the ASHG 2020 virtual meeting, representatives from both organizations laid out the reasons for their contrasting guidelines.

Incidental Findings Most Frequent in Cancer Risk Genes, EMERGE III Data Show

Researchers identified secondary or incidental findings in just over 3 percent of the nearly 22,000 EMERGE III participants, who were profiled with a 109-gene panel.

Aug 7, 2019

Australian Team Builds Federated System for Integrating Genomics Into Healthcare
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Sep 11, 2018

Yale to Launch Large-Scale Genomic Medicine Project
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Aug 9, 2018

Geisinger Team Describes Approach for Returning Secondary Genomic Findings to Research Participants

Apr 13, 2018

Secondary Findings Uncovered in 9 Percent of Parents in Trio Sequencing Study

Apr 5, 2018

Study Explores ClinVar Variant Misclassification With Population Genome, Exome Sequences

Dec 5, 2017

Kidney Disease Diagnoses Feasible by Exome Sequencing, Study Finds

Apr 3, 2017

Spera Genomics Offering Preventive Whole-Genome Sequencing to Canadian Patients
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Nov 17, 2016

ACMG Updates Secondary Findings Gene List

Sep 22, 2016

UW Team Describes Web Tool for Returning Sequencing Results; Plans New Implementations
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Sep 8, 2016

NIPT Can Reveal Maternal CNVs of Clinical Value, Belgian Study Finds
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Jan 26, 2016

Study Examines Impact of Reporting Secondary Findings

Jan 6, 2016

eMERGE PGx Study Highlights Challenges in Determining Pathogenicity, Returning Secondary NGS Results
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Oct 29, 2015

Q&A: Susan Wolf on Recommendations for Returning Genomic Results to Families of Study Participants
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Jul 2, 2015

ASHG Position Statement Provides Guidance for Genetic Testing in Children and Adolescents

Apr 29, 2015

Survey Shows Research Participants Want to Know Genomic Testing Information

Mar 30, 2015

ACMG: CHOP Team Considers Crowd Sourcing to Help Interpret Secondary Pediatric Sequencing Findings

Feb 5, 2015

Incidental Findings Challenges Point to Need for Better Databases, Population Specific References
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Jan 14, 2015

Data from Baylor-Hopkins Exomes Illustrates Challenges of Interpreting Incidental Findings
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Dec 2, 2014

Exome Tests Miss Pathogenic Variants in ACMG Recommended Genes
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Nov 19, 2014

UW Study Finds Returning Incidental Findings May be Cost Effective
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Breaking News
The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.