PTEN Mutation Syndrome Leads to Breast Cancers With Distinct Molecular Alterations
A protein-coding sequence analysis uncovered somatic mutations that distinguished breast cancers in individuals with PTEN hamartoma tumor syndrome from sporadic breast cancers.
Copy Number Variants May Influence Clinical Presentation Among Individuals with PTEN Mutations
Individuals with germline PTEN mutations who have autism spectrum disorder or developmental delay often also have copy number variations, a new study has found.
Imaging, Genetic Analysis Points to Driver Role for PTEN Loss in Ovarian Cancer
Genetic and imaging data support the idea that lower-than-usual levels of the tumor suppressor gene PTEN can drive the formation of some ovarian cancers.
Transgenomic Hopes to Attract Pharma Partners with Exclusive License to PIK3CA/PTEN PGx Testing
The patent application was filed by Montefiore Medical Center's Sanjay Goel and John Mariadason, who discovered the association between mutations in the PIK3CA and PTEN genes and a lack of response to EGFR inhibitors.
Data presented by Myriad at AACR support the "hypothesis that PTEN status predicts outcome after radical prostatectomy, and suggest further, that PTEN may be a clinically important molecular marker for defining aggressive prostate cancer."