protein-protein interaction networks Studies Unravel SARS-CoV-2 Protein Interactions With Human Proteins A pair of studies identified connections between proteins from SARS-CoV-2 and human cells, hitting on key host pathways and potential treatment targets. Disease-Linked Mutations May Affect Protein-Protein Interactions, Influence Drug Response Both germline variants and somatic tumor variants linked to disease are more likely to disrupt protein-protein interactions than other variants. Scipher Medicine, Galapagos Sign IBD Drug Development Deal The companies will jointly validate novel drug targets identified by Scipher's molecular interaction network platform for patients with inflammatory bowel disease. Scipher Medicine to Launch PrismRA Anti-TNF Response Predictor Following Positive Data Publication Premium The gene expression test retrospectively identified rheumatoid arthritis patients significantly less likely to respond to TNF inhibitor therapy. Nautilus Biotechnology Closes $76M Series B Financing Round The startup aims to develop a low-cost, high-throughput proteomics platform that combines biochemistry with computer science and information technology. Apr 8, 2020 Tens of Thousands of Protein-Protein Interactions Reported in Human Reference Interactome Map Jan 9, 2019 Scipher Medicine Builds Evidence for Tests Predicting Response to Autoimmune Disease Drugs Premium Aug 1, 2018 Researchers Develop Tool for Rapid Evolution of Useful Phenotypes in Cells Feb 13, 2018 Study Explores Genetic Overlap Between Nicotine Addiction, Schizophrenia Feb 1, 2018 Newly Funded Genome Canada Projects Focus on Proteomics, Rare Disease, Crop Genomics Premium Dec 8, 2017 Intomics Expands Protein Interaction Offering as Collaborators Report Cancer Driver Prediction Tool Premium Dec 31, 2015 IBS Researchers See DROSHA for First Time Dec 30, 2015 Researchers Model JNK Signaling to Predict Survival in Neuroblastoma Premium Jul 16, 2015 Researchers Develop New Protein-Protein Interaction Network to Explore Human Interactome Mar 4, 2015 IRB Barcelona's dSysMap Combines Mutation, Protein Structure Data to Improve Disease Studies Premium Feb 20, 2015 Computational Approach Extracts Complex Disease Insights from Incomplete Protein Interaction Network Premium Jan 15, 2015 Proximity Ligation Assays Show Potential to Detect Altered EGFR Signaling, Predict Drug Response Premium Dec 15, 2014 Pan-Cancer Study Points to Gene Networks Prone to Rare Mutations in TCGA Tumors Nov 20, 2014 Researchers Present Map of Human Protein-Protein Interactions Premium Jul 12, 2013 Toronto Team Hoping New ABC Transporter Interaction Map Will Support Drug Research, Other Clinical Efforts Premium Breaking News New Products Posted to GenomeWeb: Qiagen, Thermo Fisher, Bionano Genomics, BillionToOne, More People in the News at Illumina Ventures, Element Biosciences, Epigenomics, Exagen, More Genomic Approaches Boost Rare Disease Diagnoses in Middle Eastern Patient Population GeneDx to Raise $150M in Public and Direct Stock Offerings In Brief This Week: T2 Biosystems, Novacyt, OpGen, Dante Genomics, Nautilus Biotechnology, More The Scan Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups. Genome-Wide Analysis Sheds Light on Genetics of ADHD A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder. MicroRNA Cotargeting Linked to Lupus A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus. Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.