protein-protein interaction networks Disease-Linked Mutations May Affect Protein-Protein Interactions, Influence Drug Response Both germline variants and somatic tumor variants linked to disease are more likely to disrupt protein-protein interactions than other variants. Scipher Medicine, Galapagos Sign IBD Drug Development Deal The companies will jointly validate novel drug targets identified by Scipher's molecular interaction network platform for patients with inflammatory bowel disease. Scipher Medicine to Launch PrismRA Anti-TNF Response Predictor Following Positive Data Publication Premium The gene expression test retrospectively identified rheumatoid arthritis patients significantly less likely to respond to TNF inhibitor therapy. Nautilus Biotechnology Closes $76M Series B Financing Round The startup aims to develop a low-cost, high-throughput proteomics platform that combines biochemistry with computer science and information technology. Tens of Thousands of Protein-Protein Interactions Reported in Human Reference Interactome Map The protein-protein interactions tallied in the project are expected to inform future studies of biology and disease in various tissue and cell types. Jan 9, 2019 Scipher Medicine Builds Evidence for Tests Predicting Response to Autoimmune Disease Drugs Premium Aug 1, 2018 Researchers Develop Tool for Rapid Evolution of Useful Phenotypes in Cells Feb 13, 2018 Study Explores Genetic Overlap Between Nicotine Addiction, Schizophrenia Feb 1, 2018 Newly Funded Genome Canada Projects Focus on Proteomics, Rare Disease, Crop Genomics Premium Dec 8, 2017 Intomics Expands Protein Interaction Offering as Collaborators Report Cancer Driver Prediction Tool Premium Dec 31, 2015 IBS Researchers See DROSHA for First Time Dec 30, 2015 Researchers Model JNK Signaling to Predict Survival in Neuroblastoma Premium Jul 16, 2015 Researchers Develop New Protein-Protein Interaction Network to Explore Human Interactome Mar 4, 2015 IRB Barcelona's dSysMap Combines Mutation, Protein Structure Data to Improve Disease Studies Premium Feb 20, 2015 Computational Approach Extracts Complex Disease Insights from Incomplete Protein Interaction Network Premium Jan 15, 2015 Proximity Ligation Assays Show Potential to Detect Altered EGFR Signaling, Predict Drug Response Premium Dec 15, 2014 Pan-Cancer Study Points to Gene Networks Prone to Rare Mutations in TCGA Tumors Nov 20, 2014 Researchers Present Map of Human Protein-Protein Interactions Premium Jul 12, 2013 Toronto Team Hoping New ABC Transporter Interaction Map Will Support Drug Research, Other Clinical Efforts Premium Breaking News Pediatric Cardiomyopathy Exome Sequencing Study Suggests More Disease Genes to be Found People in the News: New Appointments at Helix, Pacific Biosciences, SomaLogic, More New Products Posted to GenomeWeb: Amoy Diagnostics, Akoya Biosciences, Congenica, Lucence In Brief This Week: BGI, Gencove, Cepheid, Biocartis, Biognosys, Co-Diagnostics, More Florida Lab Owner Pleads Guilty to $6.9M COVID-19 False Billing Scheme Pacific Biosciences Outlines Progress on Short-Read Sequencing at JPM, Partners With Canexia Health The Scan Close Panel Vote on Califf Nomination The New York Times reports there was a close committee vote to advance the nomination of Robert Califf to lead the US Food and Drug Administration to the full Senate. Task Force Reports on Scientific Integrity Nature News writes that that a new task force report recommends that the US establish a cross-agency scientific integrity council. Across the Hall Genetic testing, closed-circuit cameras, and more show how a traveler, without any contact, infected others at a New Zealand quarantine facility, CNN reports. Science Paper Examines Influence of Chromatin Modifications on Obsessive-Compulsive Disorder In Science this week: genes regulating chromatin modification may contribute to OCD risk.