protein-protein interaction networks

Researchers get a clear image of the DROSHA protein and gain a better understanding of the Microprocessor complex involved in miRNA biogenesis. 

The work offers a proof of concept for the notion that dynamic models of signaling could serve as more effective biomarkers than discrete molecular markers.

Researchers develop a method to capture protein-protein interactions as well as to gauge how frequently they occur and their strength.

Harvard researchers have developed a model of human protein-protein interactions that they said can be used to study interactome organization.

DSysMap combines mutation information with protein interaction data to provide a clearer picture of functional changes associated with the development of complex diseases.

Researchers have developed a mathematical framework for forming disease modules based on protein interaction profiles and GWAS data.

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In a study, the method was able to detect the interaction of EGFR with an associated signaling protein and predict response to targeted therapies.

Using an algorithm known as HotNet2, an international team has identified more than a dozen genetically altered sub-networks in thousands of tumor samples assessed for the Cancer Genome Atlas project.

Researchers have developed an interactome map containing some 14,000 protein-protein interactions.

Researchers from the University of Toronto have created a map of the protein interactions of 19 members of the ATP-binding cassette transporter class in a species of yeast, combining this data with previously-reported ABC transporter interactions into a comprehensive "interactome

Jay Shendure and his colleagues have developed a new method to more comprehensively identify human cell types, the NY Times reports.

Researchers in the UK and Japan have shown that infertility in mice with three sex chromosomes can be overcome, according to the Guardian.

China is embracing preimplantation genetic diagnosis, Nature News reports. 

In PLOS this week: host genetic factors associated with cervical neoplasia progression, population patterns for an ancient flowering rainforest plant, and more.