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PARP inhibitors

Breast Cancer Study Leads to New Susceptibility Gene, Potential Treatment Strategies

Researchers found risk variants in the DNA damage checkpoint gene ATRIP in a Polish founder population and linked the gene to breast cancer risk and HRD in other populations.

Tests to Guide PARP Inhibitors Emerge as New Focus for Public-Private Harmonization Effort
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Results from a homologous recombination deficiency assay concordance study led by Friends of Cancer Research were presented at the AMP annual meeting.

Thermo Fisher Introduces Homologous Recombination Deficiency Score for Cancer Profiling Assay
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The firm is also bringing its comprehensive genomic profiling assay for cancer to the Ion Torrent Genexus sequencing platform in the first half of 2023.

Myriad Genetics Gets Expanded Coverage for BRACAnalysis CDx in Japan

Testing will be reimbursed for patients with early-stage breast cancer to guide adjuvant treatment with the PARP inhibitor Lynparza.

MNM Bioscience Wins $800K Eurostars Grant to Stratify Ovarian Cancer Patients

The bioinformatics startup will work with Macrogen Europe to develop an AI-based tool for analyzing WGS data to identify patients who should receive PARP inhibitors.

Nov 4, 2021

Burning Rock, Impact Therapeutics Ink Testing Deal for ATR Inhibitor

Sep 27, 2021

Genetron Health, Impact Therapeutics Partner for Anti-Cancer Drug, CDx Development

Aug 3, 2021

Burning Rock Biotech, Impact Therapeutics Partner on CDx for PARP Inhibitor Senaparib

Jul 10, 2020

Prostate Cancer Genomics Study IDs PARP Inhibitors as Potentially Beneficial to Black Men

Aug 7, 2019

Personalis to Provide Immunogenomic Profiling for University of New Mexico Ovarian Cancer Study

Apr 18, 2019

Harvard Team Advancing Algorithmic Signature to Improve PARP Inhibitor Patient Selection
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Dec 19, 2018

FDA Approves Myriad Genetics' BRACAnalysis CDx With Lynparza in Earlier Ovarian Cancer Setting

Oct 16, 2018

FDA Approves Myriad Genetics BRCA CDx With Pfizer's Metastatic Breast Cancer Drug

Oct 10, 2018

Myriad Upgraded to Overweight by Piper Jaffray; Signs Lab Service Deal with Pfizer

Sep 28, 2018

BRCA1 Methylation Level May Predict Which Ovarian Cancer Patients Respond to PARP Inhibitors

Jul 16, 2018

PARP Inhibitors May Benefit Patients With Rare Hereditary Cancer Syndromes

May 31, 2018

PanDrugs System Aims to Advance Precision Cancer Care by Matching Treatments to Mutations
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May 11, 2018

PARP Inhibitor Resistance Gene Identified Using CRISPR Screen

Dec 8, 2017

Pfizer PARP Inhibitor Delays Progression Over Chemotherapy in BRCA-Mutated Advanced Breast Cancer
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Jul 11, 2017

After Securing CE-IVD for Debut Hereditary Cancer Dx, Korea's NGeneBio Readies NGS Tests for Launch
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Mar 27, 2017

FDA Approves Myriad Genetics' BRACAnalysis as Complementary Dx for New PARP Inhibitor

Feb 1, 2017

Clovis, Strata Partner to Identify Prostate Cancer Best Responders to PARP Inhibitor

Dec 20, 2016

Foundation Medicine's Regulatory Win for NGS CDx Sets Precedent; Adoption Challenge Remains
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Dec 19, 2016

Foundation BRCA CDx is First NGS Companion Test to Get FDA Nod

Nov 2, 2016

Myriad Moving Ahead With PMA Filing for MyChoice HRD as Companion Test for Niraparib
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Breaking News
The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.