PALB2
Ovarian Aging Study Finds Rare Variant Contributors With Ties to DNA Damage Response, Cancer
Using exome sequence data for postmenopausal UK Biobank participants, researchers focused on genes containing rare variants linked to age at natural menopause.
Healthy Nevada Researchers Consider Impact of Low Genetic Breast Cancer Risk on Screening Guidelines
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Identifying a low genetic risk group could more precisely inform when patients should start mammograms and other preventive practices, a study suggests.
Breast Cancer Incidence Dialed Down in Individuals With Low Genetic Risk
Researchers retrospectively considered breast cancer incidence by age in individuals with low breast cancer risk based on polygenic risk score and pathogenic variant profiles.
Investigational Cancer Drug Deemed Highly Mutagenic in Cell Line Sequencing Study
Using whole-genome sequencing on drug-exposed cell lines, researchers saw high mutation rates in control cell lines intermittently treated with a compound called CX-5461.
Breast Cancer Risk Contributors, Remaining Gaps Found With Familial Analyses
Segregation analyses focused on more than 17,400 breast cancer-affected families, highlighting age-related risk variants and yet-to-be-found recessive risk contributors.