NRAS

The assay can identify KRAS, NRAS, PIK3CA, BRAF, and EGFR gene mutations, as well as 19 gene rearrangements of the ALK, ROS1, RET, NTRK1, and MET genes from FFPE.

The combination of the new test with Biocartis' existing KRAS assay offers customers a complete solution for testing metastatic colorectal cancers as reccomended by professional guidelines.

Can Almost See It

Newsweek reports that cancer researchers are cautiously optimistic that they will soon be able to target mutant Ras.

One of the first projects between the firms will be to develop and commercialize a companion diagnostic for the MEK inhibitor binimetinib in NRAS-mutant melanoma.

The draft document, which includes recommendations on which molecular tests labs should perform, on what samples, and with what analytical specifications, is available for comment until April 22.

A Phase II study comparing front-line treatment with anti-EGFR drug Vectibix against anti-VEGF therapy Avastin in a genetically defined subset of metastatic colorectal cancer patients has yielded promising results in favor of the anti-EGFR agent.

EntroGen this week announced the availability of expanded colorectal cancer screening products.

Transgenomic announced this week that it has signed an agreement with Amgen to develop an IVD test to identify NRAS and KRAS mutated patients with advanced colorectal cancer using its RAScan kits.

Cepheid this week released an updated Xpert BCR-ABL Monitor test that incorporates lot-specific standardization using the World Health Organization BCR-ABL standards.

Pages

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.