NOTCH1

Researchers focused in on rare MIB1 variants overrepresented in individuals with non-syndromic bicuspid aortic valve, consistent with a role for NOTCH signaling in the condition.

The partners are working together to advance tests that will identify which cancer patients have Notch activating mutations and fusions.

Using an algorithm known as HotNet2, an international team has identified more than a dozen genetically altered sub-networks in thousands of tumor samples assessed for the Cancer Genome Atlas project.