molecular networks

Using pathway and network analyses, researchers identified overlapping genes and biological processes behind smoking and schizophrenia, including new candidate genes.

A genomic analysis of ependymomas from 42 patients led to nearly 1,700 suspected super enhancers, highlighting potentially targetable genes.

The work offers a proof of concept for the notion that dynamic models of signaling could serve as more effective biomarkers than discrete molecular markers.

The proof-of-principle application suggests networks of microRNA, RNA, and other 'omics data can untangle drug response and more.

The firms are integrating their technology platforms for drug discovery applications.

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Webb Miller, Trey Ideker, Patrick Soon-Shiong

A Whole New System

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Now in its ninth year, the experiment that was the Institute for Systems Biology has become an established research organization known for its focus on translational science.

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

The New York Times reports that evidence linking trauma in one generation to epigenetic effects that influence subsequent generations may be overstated.

ScienceInsider reports that US National Institutes of Health researchers were told in the fall they could not obtain new human fetal tissue.

In PNAS this week: skin pigmentation evolution among KhoeSan, biomarkers for dengue virus progression, and more.