molecular networks
PrecisionLife's Combinatorial Analytics Uncovers Chronic Fatigue Syndrome Susceptibility Genes
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The firm uncovered 199 SNPs clustered on 14 genes that implicated four distinct pathways to the challenging illness.
Integrated Genomic Analysis Highlights Potential Strategy for Overcoming Some ALL Resistance
The study suggested that ALL glucocorticoid resistance stemming from alterations that drive down CELSR2 levels might be combated with the BCL2-targeting drug venetoclax.
Researchers at BostonGene and Weill Cornell Medicine hope their approach may provide a more complete and precise characterization of diffuse large B-cell lymphomas.
Cancer Susceptibility Contributions of Non-Coding SNPs Clarified With Network Approach
Using systems biology, investigators put cancer risk SNPs in a network context, identifying immune, tumor-related, and other genes influenced by the variants in multiple tissue types.
Heart Failure Regulatory Gene Revealed in Tissue Transcriptome Study
Using samples from heart failure patients and healthy controls, researchers uncovered a gene that, when absent in mice, reduced their risk of heart failure.