Engineered Base Editing Tool Avoids Off-Target Mutations in Mitochondrial DNA
Researchers developed HiFi-DdCBEs, bacterial toxin DddA-derived cytosine base editors engineered to avoid spontaneous assembly of the split interbacterial toxin halves.
Team Describes 'Ongoing' Mitochondrial DNA Insertions in Human Genome
With genome sequence data for tens of thousands of individuals, researchers characterized the insertion of nuclear-mitochondrial segments in the human genome.
The Wilmington, Delaware-based startup is hoping to leverage its proprietary mitochondrial and chloroplast gene editing technology in wheat, rice, and beyond.
The technology can in principle correct almost half of pathogenic mtDNA mutations, paving the way for mitochondrial disease modeling and therapeutic applications.
Archaic Hominin History, Interactions Revealed With Denisova Cave Sediment Sequences
Investigators saw signs of Denisovans, Neanderthals, ancient modern humans, and other mammalian inhabitants in the area by enriching for mtDNA in cave sediment samples.