mismatch repair deficiency Researchers Aim to Improve Lynch Syndrome Testing With Genetic-Epigenetic Combination Method Premium The sequencing test involves a single library preparation that is then split for parallel analysis of promoter methylation, MSI calculation, and gene mutation detection. Cancer, Pathology Organizations Developing Clinical Guidelines for MMR, MSI Testing The groups have written draft recommendations and are now asking for public comment from pathologists and other stakeholders. Colorectal Cancers Dial up Mutability in Response to Targeted Treatments A new study suggests that colorectal cancers increase their mutation rate to dodge treatment in a manner that mirrors microbial resistance mechanisms. Lynch Syndrome Mutation Study Suggests Changes to Clinical Management Investigators pooled older and new data from the Prospective Lynch Syndrome Database, tracking outcomes for different mutations across age and gender groups. Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy. Jan 25, 2019 MethylDetect Looks to Leverage High-Resolution Melt Tech for Oncology Assay Development Premium Nov 8, 2018 Biocartis Microsatellite Instability Assay Validated by MSKCC, Dartmouth Researchers Premium Oct 31, 2018 Colorectal Cancer Microbiomes May Differ With Mismatch Repair Status Oct 30, 2018 Precision Oncology Highlights From ESMO 2018 Jun 4, 2018 MSI Tumor Analysis Implicates Lynch Syndrome in Several New Cancer Types Feb 20, 2018 NCCN Updated Prostate Cancer Guidelines Include New Genetic Testing Information Breaking News Children With Autism May Have Underdeveloped Gut Microbiomes, Metagenomic Analysis Finds Kiromic BioPharma Acquires InSilico Solutions Bio-Rad Laboratories, 10x Genomics Settle IP Lawsuits, Sign Global Cross-Licensing Agreement Scope Fluidics Obtains CE Mark for PCR-Based SARS-CoV-2 Panel MeMed COVID-19 Prognostic Test Receives CE Mark ERS Genomics Licenses CRISPR IP to Japan SLC The Scan Dropped Charges The US Justice Department has dropped visa fraud charges against five Chinese researchers, according to the Wall Street Journal. More Kids The Associated Press says Moderna is expanding its SARS-CoV-2 vaccine study to included additional children and may include even younger children. PNAS Papers on Rat Clues to Human Migration, Thyroid Cancer, PolyG-DS In PNAS this week: ancient rat genome analysis gives hints to human migrations, WDR77 gene mutations in thyroid cancer, and more. Purnell Choppin Dies Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.