mismatch repair deficiency Researchers Aim to Improve Lynch Syndrome Testing With Genetic-Epigenetic Combination Method Premium The sequencing test involves a single library preparation that is then split for parallel analysis of promoter methylation, MSI calculation, and gene mutation detection. Cancer, Pathology Organizations Developing Clinical Guidelines for MMR, MSI Testing The groups have written draft recommendations and are now asking for public comment from pathologists and other stakeholders. Colorectal Cancers Dial up Mutability in Response to Targeted Treatments A new study suggests that colorectal cancers increase their mutation rate to dodge treatment in a manner that mirrors microbial resistance mechanisms. Lynch Syndrome Mutation Study Suggests Changes to Clinical Management Investigators pooled older and new data from the Prospective Lynch Syndrome Database, tracking outcomes for different mutations across age and gender groups. Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations Mismatch repair-deficient tumors with many insertion-deletion mutations and enhanced microsatellite instability responded better to anti-PD-1 immunotherapy. Jan 25, 2019 MethylDetect Looks to Leverage High-Resolution Melt Tech for Oncology Assay Development Premium Nov 8, 2018 Biocartis Microsatellite Instability Assay Validated by MSKCC, Dartmouth Researchers Premium Oct 31, 2018 Colorectal Cancer Microbiomes May Differ With Mismatch Repair Status Oct 30, 2018 Precision Oncology Highlights From ESMO 2018 Jun 4, 2018 MSI Tumor Analysis Implicates Lynch Syndrome in Several New Cancer Types Feb 20, 2018 NCCN Updated Prostate Cancer Guidelines Include New Genetic Testing Information Breaking News Canadian Healthcare Providers, Policymakers Value Different Aspects of Clinical Genomic Sequencing New Products Posted to GenomeWeb: Oxford Nanopore, Bio-Rad, NanoString, More People in the News at OraSure, Element Biosciences, Micronoma, More Guardant Health Files Motions to Dismiss, Change Venue in Illumina Patent Lawsuit In Brief This Week: SQI Diagnostics, T2 Biosystems, Enhanc3D, QuidelOrtho, More Illumina, Precision Health Research Singapore Partner for 100K Genomes Population Study The Scan Blend of Omicron With Delta The Associated Press reports that currently circulating Omicron variants have some features previously seen in the Delta variant. Limited Contrast The New York Times reports that there is a shortage of a contrast agent used for some medical scans. Pig Improvement Farmers in China are using genetics to improve their hog herds, according to Reuters. Science Papers Present Way to Molecularly Classify Prostate Cancer, Saliva-Based SARS-CoV-2 Test, More In Science this week: approach to molecularly classify prostate tumors, saliva-based test for SARS-CoV-2, and more.