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methylation

An epigenetic analysis showed that the tumors all shared a certain DNA methylation signature, but that methylation patterns varied between samples.

In Genome Biology this week: epigenetic differences in CML cells, predicting aggressive prostate cancer, and more.

The qPCR-based test was shown to differentiate cancerous and non-cancerous tissue and predict biochemical recurrence, and can be used on small, degraded samples. 

This Week in PNAS

In PNAS this week: transcriptional control enables malaria parasite to get around disease control efforts, DNA methylation patterns in the Norway spruce, and more.

Dartmouth researchers characterized 5-methylcytosine and 5-hydroxymethylcytosine marks in more than two dozen glioblastoma samples.

The researchers found that 80 percent of pediatric posterior fossa ependymomas have decreased levels of H3K27me3 histone modifications.

The goal of the Texas team is to identify methylation signatures that can help with prognosis and be used to develop noninvasive tests to monitor disease progression.

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

The data make a strong case that the methylation-based assay can pick out twice as many colorectal cancer recurrences as currently used CEA testing. 

Scientists led by the Scripps Research Institute's Benjamin Cravatt have developed probes and a mass spec method to find methyltransferases in human cells.

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In Genome Biology this week: comparative genomics study of Aspergillus, genetic variation in indigenous African cattle, and more.

Some people who harbor genetic variants associated with disease show no signs and may give insight into the continuum of symptoms, Spectrum reports.

Some 57 snow monkeys at a Japanese zoo were found to be rhesus macaque hybrids, which are banned in Japan.

British researchers say they've been removed from EU grant applications, according to the Guardian.