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methylation

The qPCR-based test was shown to differentiate cancerous and non-cancerous tissue and predict biochemical recurrence, and can be used on small, degraded samples. 

This Week in PNAS

In PNAS this week: transcriptional control enables malaria parasite to get around disease control efforts, DNA methylation patterns in the Norway spruce, and more.

Dartmouth researchers characterized 5-methylcytosine and 5-hydroxymethylcytosine marks in more than two dozen glioblastoma samples.

The researchers found that 80 percent of pediatric posterior fossa ependymomas have decreased levels of H3K27me3 histone modifications.

The goal of the Texas team is to identify methylation signatures that can help with prognosis and be used to develop noninvasive tests to monitor disease progression.

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

The data make a strong case that the methylation-based assay can pick out twice as many colorectal cancer recurrences as currently used CEA testing. 

Scientists led by the Scripps Research Institute's Benjamin Cravatt have developed probes and a mass spec method to find methyltransferases in human cells.

Researchers analyzed cytosine methylation profiles for 34 angiosperm plants, considering methylation levels and distribution across flowering plant families.

Through their combined genetic and epigenetic study of schizophrenia, the researchers have generated a list of genes affected by risk factors for the disease.

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In Science this week: metagenomic-based technique for determining protein structure, and more.

An academic laments the rise of narcissism in the sciences, the Guardian reports.

Outgoing FDA commissioner Robert Califf writes in an editorial that the agency can help boost innovation.

The Trump transition team has asked NIH Director Francis Collins to remain at his post, though it's unclear for how long that will be.