MEK inhibitors
The assay examine phenotypic behaviors of isolated cancer cells from biopsies at initial diagnosis.
Qiagen Inks Master CDx Collaboration With Array BioPharma
One of the first projects between the firms will be to develop and commercialize a companion diagnostic for the MEK inhibitor binimetinib in NRAS-mutant melanoma.
FDA Approves New MEK/BRAF Inhibitor Option for Melanoma Patients with BRAF V600E, V600K Mutations
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Before patients receive the Cotellic/Zelboraf combination, patients should be tested with an FDA-approved BRAF mutation companion test, the agency said.
"Seeing that we have had other agents in this class, there should be some sort of selection of tumor types, or some type of genomic profiling, or at least retainment of archival tissue, so that we can go on to profile these patients at a later date," said Patricia LoRusso of Karmanos Cancer Institute at Wayne State University, who reviewed early dosing trials of three MEK inhibitors being developed by GlaxoSmithKline, Merck Serono, and Eisai.