long non-coding RNAs

This Week in Science

In Science this week: influence of gut microbiome metabolism on host, and more.

A short pyknon motif on the lncRNA N-BLR appears to mediate its effect on cells' ability to metastasize and invade in colorectal cancer, researchers found.

The FANTOM consortium generated an atlas of nearly 30,000 human long non-coding RNAs that suggests more than 19,000 of them are functional.

The transient transcriptome sequencing protocol relies on combining sequencing with 4-thiouridine labeling and RNA fragmentation.

A genome-wide association suggests an African-specific lincRNA allele on chromosome 7 contributes to risk of bloodstream infection by Streptococcus pneumoniae.

In Genome Biology this week: computational approach to tease apart clonal tumor lineages, cell type-specific lncRNA expression in developing human neocortex, and more.

Qiagen has submitted an offer to buy all of Exiqon's shares for DKK18 each, for a total aggregate purchase price of DKK683 million ($103.5 million).

With the help of TCGA sequence data, researchers uncovered expression of a long, non-coding RNA called SAMMSON that appears to be specific to melanoma.

In Genome Biology this week: inter-individual variability of long non-coding RNAs, computational approach for removing low-quality cells from single-cell analyses, and more.

The researchers said that long non-coding RNAs showed more specificity to different cancer types than protein-coding genes, making them important, precise biomarkers.

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Rare gene mutations are guiding the search for drugs to manage chronic pain without opioids, according to CNBC.

The new Francis Crick Institute building can get too noisy for some researchers to concentrate, according to the Guardian.

CBS News reports that there are still many vacancies at the White House Office of Science and Technology Policy, but that it's uncertain whether they will be filled.

In Nucleic Acids Research this week: pipeline to analyze and visualize bacterial genomes, database of global set of human genomes, and more.