long non-coding RNAs

This Week in Science

In Science this week: influence of gut microbiome metabolism on host, and more.

A short pyknon motif on the lncRNA N-BLR appears to mediate its effect on cells' ability to metastasize and invade in colorectal cancer, researchers found.

The FANTOM consortium generated an atlas of nearly 30,000 human long non-coding RNAs that suggests more than 19,000 of them are functional.

The transient transcriptome sequencing protocol relies on combining sequencing with 4-thiouridine labeling and RNA fragmentation.

A genome-wide association suggests an African-specific lincRNA allele on chromosome 7 contributes to risk of bloodstream infection by Streptococcus pneumoniae.

In Genome Biology this week: computational approach to tease apart clonal tumor lineages, cell type-specific lncRNA expression in developing human neocortex, and more.

Qiagen has submitted an offer to buy all of Exiqon's shares for DKK18 each, for a total aggregate purchase price of DKK683 million ($103.5 million).

With the help of TCGA sequence data, researchers uncovered expression of a long, non-coding RNA called SAMMSON that appears to be specific to melanoma.

In Genome Biology this week: inter-individual variability of long non-coding RNAs, computational approach for removing low-quality cells from single-cell analyses, and more.

The researchers said that long non-coding RNAs showed more specificity to different cancer types than protein-coding genes, making them important, precise biomarkers.

Pages

The Jackson Laboratory has filed a complaint accusing Nanjing University of breeding and re-selling its mouse models, the Hartford Courant reports.

Oxford researchers are turning to virtual reality to visualize genes and regulatory elements, Phys.org says.

In Science this week: neutrophils rely on microRNA to protect against lung inflammation, and more.

China is moving forward with plans to sequence a million citizens, the Wall Street Journal reports.