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KRAS Biomarkers

News and reporting on KRAS biomarkers.

Two studies published earlier this month in Nature have demonstrated how Inostics' BEAMing digital PCR/flow cytometry technology can be used to detect drug resistance mediated by KRAS mutations in colorectal cancer patients months before treatment failure is observed.

This article has been updated from a previous version to correct the list price of the QX100 system.

A new assay dubbed Allele Specific Locked Nucleic Acid quantitative PCR, or ASLNAqPCR, can identify and quantitate KRAS and BRAF mutations from a variety of sample types with 100 percent specificity, and greater accuracy and higher analytical sensitivity than Sanger sequencing, a

This article has been updated from a previous version to include information about the current status of Fluidigm's collaboration with Novartis.

After a survey of UK oncologists revealed that access hurdles and high costs associated with biomarker testing are limiting their ability to prescribe personalized treatments, Merck Serono has issued a "call to action" for the government and pharmaceutical industry to work togeth

By Ben Butkus
Life Technologies this week announced the expansion of its TaqMan Mutation Detection Assays based on competitive allele-specific TaqMan, or Cast, PCR technology.

By Ben Butkus
RainDance Technologies has launched its digital PCR platform for applications such as rare allele detection and copy number variation analysis.

Originally published Jan. 16.
In a pharmacogenetic investigation conducted by researchers in the Netherlands, Bayer's Nexavar was not able to improve survival in patients with KRAS-mutated non-small cell lung cancer.

The headline and this story have been updated to reflect that BMS and Lilly have submitted to the FDA retrospective analysis on Erbitux's efficacy in colorectal cancer patients with wild-type KRAS mutations, which the agency may use to update the drug label.

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The Washington Post reports that the CDC's SARS-CoV-2 test issues reflect earlier ones it had with Zika virus testing.

NPR writes that even with thousands of new COVID-19 papers, each should be evaluated based on its own quality.

Researchers traced a gene cluster linked to COVID-19 severity to Neanderthals, the New York Times reports.

In PNAS this week: soil bacteria-derived small molecules affect centrosomal protein, microfluidics approach for capturing circulating tumor cells, and more.