HLA typing

The workflow was cleared by the South Korean Ministry of Food and Drug Safety for the typing of HLA-A, B, C, DRB1, and DQB1 by next-generation sequencing.

The Boston-based startup wants to help individuals interpret their HLA data for ancestry and health, and participate in research studies. 

Researchers genotyped advanced cancer patients treated with immunotherapies and found that homozygosity at HLA loci was linked to decreased survival.

The kits cover the primary genetic targets currently used for assessing the compatibility of  hematopoietic cell donors with recipients.

The software provides analysis of HLA typing by NGS on several platforms, including ones from Illumina, Thermo Fisher, and PacBio.

The company said revenues from its non-invasive heart transplant rejection test AlloMap rose about 16 percent year over year.

Linkage is now part of Thermo Fisher's transplant diagnostics business, One Lambda. Linkage's flagship product line is its real-time PCR technology, LinkSeq.

This Week in PNAS

In PNAS this week: sand rat genome assembly, algorithm for human leukocyte antigen typing from short-read data, and more.

This Week in Science

In Science this week: a protective gene in C. elegans, and combining EHRs with genetic data to ID HLA-associated variants

An international team of researchers has mapped new associations between HLA mutations and specific diseases, and made their data freely accessible.


360Dx reports that the US Centers for Medicare & Medicaid Services would cover next-generation sequencing-based cancer panel tests.

The Washington Post reports that a meteorologist is being considered as presidential science and technology advisor.

In PNAS this week: precision medicine strategy to screen for disease risk, genome evolution in Haemophilus influenzae, and more.

Researchers have developed a PCR-based assay to gauge whether manatees are present in waters.