HLA COVID-19 Protection Provided by HLA Genetic Variant, Study Suggests Using data from bone marrow registry participants, researchers found an HLA variant linked to symptom-free SARS-CoV-2 infection and better immune cell responses. Tempus, TScan Therapeutics Partner on CDx for T-Cell Receptor Therapy in Solid Tumors The companies will collaborate to develop a companion diagnostic to support TScan's screening protocol for its Phase 1 solid tumor clinical trial. Mnemo Therapeutics Identifies Possible New Class of Cancer Therapeutic Target Premium The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells. Somatic Mutations in Lung Cancer Patients With HLA Supertype B44 Influence Immunotherapy Response The B44 supertype is associated with improved survival in melanoma patients treated with immunotherapy, but less so in NSCLC patients, due to mutational differences. CareDx Hybrid Capture Tech for HLA Testing Receives CE Marking The company, which launched the technology in September 2019, said in its Q4 earnings release that it received high marks from beta testers. Jan 28, 2019 Analysis of Major Histocompatibility Complex Region Highlights Diversity Jun 15, 2018 Sanofi Enlists Linguamatics to Discover New Multiple Sclerosis Biomarkers Premium May 10, 2018 CareDx Q1 Revenues Up 21 Percent May 9, 2018 CareDx Licenses Illumina NGS Transplant Clinical Application Products Feb 2, 2018 HLA Variants Key to Predicting Kidney Transplant Outcomes Feb 1, 2018 Root to Provide Personal HLA Data, Interpretation to Bone Marrow Donor Registry Members Premium Dec 7, 2017 Immunotherapy Response Influenced by Cancer Patients' HLA Genotypes Sep 21, 2015 Boston Team Applies Polysolver Method to Detect HLA Mutations in Whole-Exome Sequencing Data Premium Jul 6, 2015 Following Feasibility Study, UK Registry Plans to Implement PacBio for HLA Typing by Year's End Premium Jun 9, 2015 Linkage Bio Receives CE Mark for HLA Test Apr 28, 2015 Study Finds Markers of Rheumatoid Arthritis Risk Also Predict Severity and Drug Response Premium Jan 22, 2015 U of Toronto Team Sequences Three Clinically Relevant Human Genes with Oxford Nanopore MinIon Premium Apr 21, 2011 Abbott to Distribute Biofortuna's Freeze-Dried HLA Typing Kits Premium Sep 30, 2010 Biofortuna Unveils One-Step Freeze-Dried PCR Kit for HLA Market Premium Breaking News Rare Kidney Cancer Genomic Analysis Reveals Potential Target, Suggests Treatment SEC Concludes CareDx Investigation, Recommends No Enforcement Action Streck Quality Controls for DiaSorin's Luminex Sepsis Tests Receive FDA Clearance Adela Closes $48M Financing to Develop Cancer Monitoring, Early Detection Test 3EO Health At-Home Molecular COVID-19 Test Nabs FDA EUA The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.