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Jul 17, 2018

Strata Oncology to Aid Puma Biotech in Recruiting for Neratinib HER2 Basket Study

Strata will refer individuals with HER-2 mutations identified through its screening trial for consideration as subjects in Puma's SUMMIT trial.

Feb 01, 2018

Publication Highlights Key Questions as Basket Studies Proliferate

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The analysis of HER2 and HER3 mutation carriers emphasizes how these studies can lead both to broadening and to narrowing of the patient populations for targeted drugs.

Apr 12, 2017

After Korean Clinical Approval for Breast Cancer Prognostic, Gencurix Looks to Asian, US Markets

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Gencurix aims to achieve US FDA 510(k) clearance for its GenesWell BCT breast cancer prognostic test next year.

Apr 03, 2017

HER2 Mutant Basket Trial Confirms Drug Response Depends on Mutation, Cancer Type

At the AACR annual meeting, researchers presented results from the Phase II SUMMIT trial investigating the pan-HER-targeted therapy neratinib.

Mar 18, 2016

MD Anderson Researchers Develop New Breast Cancer Staging System

The new system emphasizes the importance of tumor biology as an important prognostic indicator for women who undergo neoadjuvant therapy, the researchers said.

Jun 04, 2015

Study Suggests Surrogate Endpoint May Reflect Longer Benefit of Early HER2 Breast Cancer Treatment

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Data showed that patients who had pathologic complete response in the neoadjuvant setting after treatment with a regimen containing Genetech's Perjeta experienced better progression-free and disease-free survival.

Jul 02, 2014

Roche Buying Seragon to Strengthen its Breast Cancer Pipeline, Improve Upon Standard Hormone Therapy

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NEW YORK (GenomeWeb) – Roche this week announced plans to acquire Seragon Pharmaceuticals, aiming to bolster its own breast cancer pipeline and improve the standard of care for hormone receptor-positive breast cancer.

Dec 11, 2013

Genomic Stratification Results Support Finding of Herceptin Response in HER2-Negative Patients

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A new study using gene expression profiling to divide patients from an adjuvant trastuzumab (Herceptin) clinical trial into subgroups based on their response to the drug has shown that adjuvant treatment in addition to chemotherapy might be effective even in HER2-negative patient

Oct 09, 2013

ASCO, CAP Update Guidelines for HER2 Testing in Breast Cancer Patients

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The American Society for Clinical Oncology and the College of American Pathologists have jointly issued updated guidelines in which they continued to recommend that oncolo

Jul 03, 2013

FDA Grants Priority Review to Genentech's Perjeta sBLA for Neo-Adjuvant HER2 Breast Cancer

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The US Food and Drug Administration has accepted a supplemental biologics license application for Perjeta (pertuzumab) as a neoadjuvant treatment for women with HER2-positive, early-stage breast cancer, Roche subsidiary Genentech announced this week.

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The Scan

The Fall of the Yellow-Banded Bumblebee

York University researchers find genomic evidence of inbreeding in the yellow-banded bumblebee, according to Reuters.

If It Is to Help

In its survey of US adults, the Pew Research Center finds that views on the genetic engineering of animals depend on why it's done.

Bunch at Once

The Scientist reports agricultural researchers are working on a gene-stacking tool.

This Week in Nature

In Nature this week: statistical method for overcoming case-control imbalance issues, and more.

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