haplotype

The method generates megabase-scale phased haplotype blocks and can be automated and scaled up to process samples for population sequencing projects.

This Week in Nature

In Nature this week: mitochondrial genome of extinct South American ungulate, and more.

Researchers showed in a new study that patterns of methylation co-occuring at different sites could help distinguish cancer DNA in the blood, and mark its original source in body.

The approach, which uses 10x Genomics technology for haplotyping, requires neither mutation-specific assays nor DNA from affected family members.

The PGP team used Complete Genomics' Long-Fragment Read technology to analyze the set of samples.

Researchers identified some 1.9 million structural variants using whole-genome sequence data from 250 families profiled for the Genome of the Netherlands project.

Researchers demonstrated that Strand-seq directional single-cell sequencing can be used to assemble consensus chromosome haplotypes for an individual.

The researchers said that the method, known as STITCH, could make it possible to perform GWAS on non-human organisms and demonstrated it on 2,000 mice. 

The hybrid approach expands on one described last year by Mount Sinai researchers, and relies on short-read sequencing, linked-read sequencing, and genome mapping.

The firm will use the latest investment to support marketing and sales of its linked-read platforms and support development of future products.

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Gene drives might run into biological resistance, the Economist reports.

Forensic experts exhumed painter Salvador Dalí's body to collect DNA for a paternity test, CBS News reports.

Yale Environment 360 writes that synthetic and conservation biologists aren't always on the same wavelength, but they are trying to reach an understanding.

In Science this week: full CRISPR locus integration complex structure, and more.