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GWAS

A team of researchers from the National Institutes of Health and elsewhere has developed a likelihood-based statistical framework that can identify individual participants in genome-wide association studies.

Using a genome-wide association study combined with targeted gene re-sequencing and reciprocal allele-specific RNA interference, German and French researchers have pinpointed a mosquito gene involved in malaria parasite resistance.

Despite experiencing "some weakness" in demand for its whole-genome genotyping chips in recent quarters, Illumina expects the genome-wide association studies market to revive by the middle of next year, and believes its array business will continue to grow, driven by the agricultural biotechnology market and custom projects.

Using a small interfering RNA screen, an American research team has identified biological pathways that interact with — and apparently regulate — the circadian clock in a human cell line.

Some participants at this year's Human Genome Variation and Complex Genome Analysis meeting believe array-based genome-wide association studies similar to those conducted over the past few years will continue into the future, but several factors will likely affect how the GWAS market develops.

Following the GWAS, researchers plan to conduct a prospective, randomized-controlled trial and form a pharmacogenomics consortium specifically focused on validating and discovering new gene-response variants for clopidogrel.

A team of scientists led by researchers at the University of Maryland Medical School reports today in JAMA that CYP2C19*2 influences Plavix treatment response as well as the frequency of coronary problems in those at higher risk of such events.

Using a data from a GWAS of almost 1,700 hepatitis C patients, researchers from Duke and Johns Hopkins University and Schering-Plough Research Institute have identified a biomarker for HCV treatment response.

According to CEO Kevin King, Affy's "efforts to prepare the company for renewed revenue growth and profitability … have started to pay off."

The study, conducted with samples from more than 1,000 African Americans, identified multiple SNPs around five genes that may lead to the development of new treatments and prevention strategies for hypertension.

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New analyses indicate the P.1 variant found in Brazil may be able to infect people who have already had COVID-19, the New York Times reports.

According to CNBC, Novavax's CEO says its vaccine could be authorized in the US as early as May.

The US National Institutes of Health has a new initiative to address structural racism in biomedical research.

In PNAS this week: GWAS of TLV-1-associated myelopathy/tropical spastic paraparesis, analysis of twins with hypertrophic cardiomyopathy, and more.