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Researchers combined genome-wide association and transcriptome study data to uncover cell types affected by complex brain disorders, including Parkinson's disease.
Researchers used case and control genotypes alongside related trait, transcriptome, and population data to identify 85 cutaneous melanoma candidate loci.
In PNAS this week: common variants associated with complement factor H binding, DNA metabarcoding-based study of boreal wetland, and more.
Combining questionnaire-derived phenotyping with hospital diagnoses increases the power to tease out genetic associations within biobank data.
A new study showed that relying on minimal phenotyping could impede researchers' ability to identify genetic pathways specific to major depressive disorder.
Using data for more than half a million individuals, researchers identified 449 refractive area-related loci, including 336 sites not linked to the eye condition in the past.
In Nature this week: hybridization and introgression affected genetic diversity of Dutch elm disease, genetic and phenotypic landscape of mitochondria in a Japanese population, and more.
In PNAS this week: 10-SNP polygenic risk score for papillary thyroid cancer performs as well as a larger one, loss-of-function mutation affecting voltage-gated sodium channel, and more.
In PLOS this week: transcriptomic and genomic analysis of prostate cancer by ancestry, genes linked to liver function in Korean cohort, and more.
With data from UK Biobank participants, investigators identified dozens of snoring-related genetic loci and links to traits such as weight, smoking, and sleep apnea.
New analyses indicate the P.1 variant found in Brazil may be able to infect people who have already had COVID-19, the New York Times reports.
According to CNBC, Novavax's CEO says its vaccine could be authorized in the US as early as May.
The US National Institutes of Health has a new initiative to address structural racism in biomedical research.
In PNAS this week: GWAS of TLV-1-associated myelopathy/tropical spastic paraparesis, analysis of twins with hypertrophic cardiomyopathy, and more.