GWAS

In animal models, loss of ALK was associated with protection from obesity, even when the animals were on a high-fat diet.

A genome-wide association study on hundreds of thousands of women with or without breast cancer implicated 32 new risk loci, including sites associated with specific subtypes.

The variant also appears to be under positive selection and is more common among coastal Peruvians.

A GWAS that incorporated magnetic resonance imaging data for UK Biobank participants led to 45 previously undetected risk loci related to dilated cardiomyopathy.

With genome sequences for nearly 900 individuals with primary immunodeficiency, researchers identified candidate genes and common variant contributors.

The researchers said the findings underscore the need to study disease variants in a range of ancestral backgrounds.

Researchers combined genome-wide association and transcriptome study data to uncover cell types affected by complex brain disorders, including Parkinson's disease.