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A genome-wide meta-analysis involving more than 435,000 individuals also linked problematic alcohol use with other substance abuse and psychiatric disorders.
In animal models, loss of ALK was associated with protection from obesity, even when the animals were on a high-fat diet.
A genome-wide association study on hundreds of thousands of women with or without breast cancer implicated 32 new risk loci, including sites associated with specific subtypes.
In Nature this week: missense variant linked to decreased height among Peruvians, genetic basis of sex-biased vulnerability to certain disorders, and more.
The variant also appears to be under positive selection and is more common among coastal Peruvians.
A GWAS that incorporated magnetic resonance imaging data for UK Biobank participants led to 45 previously undetected risk loci related to dilated cardiomyopathy.
With genome sequences for nearly 900 individuals with primary immunodeficiency, researchers identified candidate genes and common variant contributors.
The researchers said the findings underscore the need to study disease variants in a range of ancestral backgrounds.
In Nature this week: combining genome-wide association and transcriptome study data homes in on cells involved in brain disorders, and more.
Researchers combined genome-wide association and transcriptome study data to uncover cell types affected by complex brain disorders, including Parkinson's disease.
Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.
Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.
Science reports that a Dutch research funding agency is combating a ransomware attack.
In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.