Researchers prioritized schizophrenia risk SNPs from genome-wide association studies and used functional genomics to find transcription factor-disrupting risk SNPs.
The findings underscored links between depression and other conditions and suggested a number of potential new targets for treatment with existing drugs.
Several of the novel variants the researchers identified are more common among individuals of Japanese ancestry than of European background.
In Nature this week: snapdragon genome assembly, genome-wide association study of circadian rhythms, and more.
Using UK Biobank and 23andMe data, researchers found 352 loci influencing sleep time preferences, including sites near brain- and retina-expressed genes.
In PLOS this week: statistical approach for integrating eQTL and GWAS data, microRNA signature distinguishes malignant and benign salivary gland tumors, and more.
Researchers saw variants contributing to both ends of the weight spectrum by analyzing thousands of thin, early-onset obese, and population control individuals.
One locus appears to be more common among individuals with Native American or East Asian ancestry and suggests there was convergent evolution of skin color among Eurasians.
A number of the genes implicated are also the targets of approved therapeutics or of ones under testing.
In Nature this week: improved genomic analysis using a graph genome reference, tumor mutational burden could predict clinical response to immune checkpoint inhibitors, and more.
The World Health Organization has announced the members of its gene-editing committee, according to NPR.
DARPA is working on developing algorithms that gauge the credibility of research findings, Wired reports.
The American Society of Breast Surgeons recommends all women diagnosed with breast cancer be offered genetic testing, the Washington Post says.
In Science this week: comparison of modern, historical rabbit exomes uncovers parallel evolution after myxoma virus exposure; and more.