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GWAS

Researchers have tied nearly 200 candidate genes, including ones involved in neurodevelopment, apoptosis, and inflammation, to the volume of brain structures.

According to simulations and a study of large families presented at ASHG this week, current polygenic scores cannot accurately predict complex human traits.

The search uncovered two post-traumatic stress disorder loci in Europeans and a third in individuals with African ancestry, highlighting immune- and brain-related genes.

In PNAS this week: cell line to assay myotonic dystrophy type 1 therapies, gene involved in rice architecture, and more.

The results of the study, which involved more than 47,000 MS patients and 68,000 unaffected controls, explain almost half of the disease's estimated heritability.

The researchers conducted genome-wide association studies of individuals who reported hearing difficulties and those who used hearing aids.

Researchers also uncovered associations between any psychotic experience and the genetic liability for schizophrenia, major depressive disorder, and bipolar disorder.

Researchers linked 16 genetic loci to diabetic kidney disease, including a common missense mutation in the COL4A3 gene that appears to be protective.

A Mendelian randomization analysis found visceral fat to be linked to cardiometabolic disease risk, especially type 2 diabetes risk in women.

In Science this week: sequencing study of 523 ancient individuals from South and Central Asia, and more.

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Russian CRISPR researcher moves along with plans to ultimately alter the genes of embryos of deaf couples, though awaits regulatory approval, Nature News reports.

University of California, San Francisco, researchers have uncovered a gene mutations that appears to make a father-son duo more efficient sleepers.

NPR reports a large health insurer has begun to cover some pharmacogenetic tests for psychiatric drugs.

In PLOS this week: genome-wide association study of non-syndromic orofacial cleft subtypes, epigenetic and transcriptomic analysis of pancreatic ductal adenocarcinoma, and more.