GWAS Building off ChatGPT Popularity, Generative AI Starts Finding its Place in Genome Informatics Premium Bioinformaticians, researchers, and commercial software developers worldwide are trying to harness the power of generative AI for genomics without compromising scientific integrity. Multi-Ancestry GWAS Improve Polygenic Risk Scores for Understudied Populations Investigators led by a team at the Broad Institute used simulations and empirical analysis to compare the performance of PRS derived from single- and multi-ancestry GWAS. Schizophrenia Risk Variants Functionally Validated With Massively Parallel Reporter Assay Investigators used an MPRA to functionally validate more than 5,000 schizophrenia GWAS variants in primary human neural progenitor cells. Hundreds of Hypertension-Related Effector Genes Identified in Genetic Fine-Mapping Study Investigators used genetic fine mapping and multiomics to identify 436 blood pressure-related candidate effector genes, some of which could become drug targets. Esophageal Cancer Susceptibility Risk Variants Found in South African Population Using GWAS data, researchers identified esophageal squamous cell carcinoma risk variants that overlap with those found in a high-risk population in China. Aug 31, 2023 GWAS Meta-Analysis Identifies 26 Risk Loci Linked to Epilepsy Aug 29, 2023 Study Finds Mechanism Linking Noncoding Risk Locus, Disease-Related Cellular Phenotypes Aug 24, 2023 GWAS Links Gene Variant to Parkinson's Disease Risk in People of African Ancestry Aug 10, 2023 Study Links Lung Cancer Risk to Genetic Variants Implicated in Alternative Splicing Aug 4, 2023 Menopause GWAS Uncovers Genetic Contributors with Age-Specific Effects Aug 2, 2023 Multiomics Helps Identify Potential Drug Targets for Dyslipidemia Jul 21, 2023 Chinese Population Biobank Highlights Genetic Diversity, Disease Associations Jul 20, 2023 GWAS of UK Biobank Participants Reveals Genetic Loci Linked to Human Skeletal Formation Jul 18, 2023 Rare Urinary Bladder Disease GWAS Points to Importance of Autoimmunity, Inflammation Jul 14, 2023 Participation in Genetic Studies Has Ties to DNA, UK Biobank Study Shows Jul 11, 2023 Type 2 Diabetes, Osteoarthritis Comorbidity Traced to Obesity-Related Processes Jun 29, 2023 Study Finds Genetic, Nongenetic Ties to Nonresponse Behavior in Surveys Jun 28, 2023 Multiple Sclerosis GWAS Points to Role for Central Nervous System in Disease Severity, Progression Jun 22, 2023 Nasopharyngeal Carcinoma Risk Genes Identified, Characterized Jun 16, 2023 Study Compares Abilities of Various Genetic Approaches to Identify Drug Targets Jun 15, 2023 Hand Condition Contributors Include Variants Passed Down From Neanderthals Jun 9, 2023 GWAS Links Human Voice Pitch to Gene Influencing Cardiovascular, Hormonal Processes May 31, 2023 Heart Disease Risk Variants, Genes Found in GWAS Meta-Analysis May 25, 2023 Epilepsy Linked to Alzheimer's Disease Risk Variants in New Analysis May 24, 2023 Blood Pressure Genetic Variants Linked to Regulatory Functions, Cardiovascular Pathways Load More Breaking News Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center In Brief This Week: DermTech, Cerca Biotech, Colossal Biosciences, Biocept, Abbott, More Cue Health to Implement Shareholder Rights Plan BioMérieux Submits Dual FDA Marketing, CLIA Waiver Application for Respiratory, Sore Throat Panel GA4GH Announces 10 New 'Driver' Projects, Including First Pediatric Partner The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.