Results from some 4,200 GWAS suggest a significant subset of genetic loci contribute to multiple complex traits, though the type of overlap further varied at the gene and SNP levels.
Researchers focused on candidate genes near expression quantitative trait loci identified by combining cancer susceptibility SNPs and available transcriptomic data.
In European American military veterans, the study led to several genetic loci with ties to the severity of a core PTSD symptom known as reexperiencing.
A large genome-wide association meta-analysis and follow-up analyses revealed eight risk loci involving SNPs previously associated with body traits, metabolism, and psychiatric risk.
Some of the loci suggest potential treatment options with drugs that modulate LDL cholesterol, the LPL pathway, or circulating lipoprotein(a), the researchers said.
The US National Institutes of Health's All of Us project awarded $4.6 million to the company Color to develop a genetic counseling resource for the program.
