GWAS
Polygenic Risk Prediction Improves With Functional Annotation Data
Researchers developed a framework known as OmniPRS to boost PRS prediction accuracy by incorporating functional annotation data in simulated and real datasets.
Infertility GWAS Leads to Genetic Risk Loci, New Reproduction Insights
After identifying 22 loci associated with female infertility and three with male infertility, researchers explored ties to other reproductive conditions and to hormone levels.
Osteoarthritis Risk Genes, Treatment Targets Unearthed in GWAS Meta-Analysis
Researchers identified 962 osteoarthritis risk variants and potentially targetable effector genes using genetic data for 489,975 cases and nearly 1.5 million unaffected controls.
Heart Failure Genetic Study Highlights Interplay Between Common, Rare Risk Variants
Along with rare disease variants found in exome or genome sequence data, researchers identified common variants that combine to influence heart failure risk.
UK Biobank Plasma Proteomic, Genetic Study Uncovers Asthma Biomarkers, Drug Targets
Researchers from Genentech focused in on blood plasma proteins linked to asthma, including potential disease biomarkers and drug targets.