Researchers have tied nearly 200 candidate genes, including ones involved in neurodevelopment, apoptosis, and inflammation, to the volume of brain structures.
According to simulations and a study of large families presented at ASHG this week, current polygenic scores cannot accurately predict complex human traits.
The search uncovered two post-traumatic stress disorder loci in Europeans and a third in individuals with African ancestry, highlighting immune- and brain-related genes.
The results of the study, which involved more than 47,000 MS patients and 68,000 unaffected controls, explain almost half of the disease's estimated heritability.
Researchers also uncovered associations between any psychotic experience and the genetic liability for schizophrenia, major depressive disorder, and bipolar disorder.
Russian CRISPR researcher moves along with plans to ultimately alter the genes of embryos of deaf couples, though awaits regulatory approval, Nature News reports.
In PLOS this week: genome-wide association study of non-syndromic orofacial cleft subtypes, epigenetic and transcriptomic analysis of pancreatic ductal adenocarcinoma, and more.
