GWAS

The international team of researchers uncovered 535 novel risk loci for blood pressure in its analysis, which drew on more than one million people.

These and previously uncovered multiple myeloma risk loci may influence disease by affecting developmental transcriptional regulators.

A meta-analysis involving 16,595 women with leiomyoma and 523,330 without led to 16 associated loci related to both tumorigenesis and estrogen-related traits.

Genes and pathways related to mesenchymal biology, connective tissue, and conditions like obesity came to the forefront when researchers analyzed the new susceptibility loci.

Using data for more than 500,000 individuals, researchers found 15 fracture-linked loci and saw genetic interactions between fracture and bone mineral density.

Genome-wide polygenic risk scores highlight those at risk of coronary artery disease, atrial fibrillation, type 2 diabetes, IBD, and breast cancer.

With genotyping data for more than 100,000 endometrial cancer cases and controls, researchers found nine new risk loci before delving into genes and pathways involved.

Researchers integrated results from a pathogen-host association study with available clinical data to find variants influencing both infection responses and other disease risks.