GWAS Type 2 Diabetes Mechanisms, Risk Genes Identified in GWAS Meta-Analysis Researchers uncovered candidate risk genes and potential mechanisms and conducted further analyses of proinsulin-associated risk loci. Analysis Highlights Plasma Metabolites With Roles in Common Diseases According to the researchers, these metabolites could potentially be targeted by drugs to manage disease. Varicose Vein GWAS Points to Vascular Risk Loci, Potential Treatment Targets Starting with a multi-ancestry genome-wide association study, researchers unearthed varicose vein-related variants, along with related traits and treatment targets. Multiomic Study Points to New Colorectal Cancer Risk Contributors Researchers tracked down more than 100 new risk variants with a combination of genomic, transcriptomic, and methylation analyses, highlighting new and known risk pathways. Study Finds Genetic Roots of Brown Coloring in Black Bears With genome sequences from hundreds of American black bears, researchers narrowed in on a loss-of-function TYRP1 variant that is associated with brown fur. Dec 14, 2022 GWAS of Veterans Ties Four Genetic Loci to Risk of Suicidal Thoughts, Behaviors Dec 7, 2022 Tobacco, Alcohol Use Contributors Uncovered With Multi-Ancestry GWAS Dec 5, 2022 Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across Psychiatric Conditions Nov 29, 2022 Alzheimer's Disease Genes, Treatment Targets Identified With Deep Learning Method Nov 21, 2022 New Osteoarthritis Genetic Risk Loci Uncovered in Multi-Ancestry Analyses Nov 17, 2022 Non-Random Mating May Exaggerate Findings of Pleiotropy in Population Genetic Studies Nov 3, 2022 Meta-Analyses Hint at Severe COVID-19 Risk Factors, Ties to Autoimmune Disease Oct 24, 2022 Liver Disease Multiomic Analysis Reveals Detection Clues, Points to Treatment Strategies Oct 20, 2022 Dyslexia GWAS Leads to Dozens of Risk Loci, Polygenic Risk Score Oct 18, 2022 Hip Fracture GWAS, Mendelian Randomization Reveal Risk Loci Oct 12, 2022 Global Biobank Meta-Analysis Initiative Brings Greater Diversity to Global GWAS Oct 12, 2022 GWAS of More Than Five Million People Uncovers Thousands of Height-Associated SNPs Oct 5, 2022 Korean Biobank Data Analysis Uncovers More Than a Hundred Novel Genetic Associations Through GWAS Sep 30, 2022 Stroke Risk Contributors, Treatment Targets Uncovered in Cross-Ancestry GWAS Sep 29, 2022 Integration of Single-Cell RNA-seq, Genomic Data Reveals Cell Types Involved in Genetic Diseases Sep 26, 2022 Autism, ADHD Found to Have Overlapping and Distinct Genetic Contributions Aug 25, 2022 New Genes Linked to Word-Reading Ability in Genome-Wide Study From International Consortium Aug 22, 2022 Study Follows Geographic Impacts on Apparent Heritability of Complex Traits Aug 15, 2022 Phenotype Ties to Rare Variants Systematically Unearthed in UK Biobank Exomes Aug 10, 2022 UK Biobank Copy Number-Based GWAS Discovers New Associations With Human Traits Load More Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.