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GWAS

By uncovering genetic factors behind blood and urine biomarkers, researchers came up with polygenic scores related to biomarker status and related disease risk.

The findings further suggested the gut microbiome could influence conditions like inflammatory bowel disease and serve as therapeutic targets.

In Science this week: analysis of genome-wide association studies of chronic kidney disease, and more.

The researchers developed an approach to mitigate the effects of misreporting or longitudinal changes in drinking behavior.

In Genome Biology this week: loci linked to longitudinal pediatric bone accrual, role of complement cascade gene in pancreatic cancer metastases, and more.

In a genome-wide association study of Takayasu arteritis, researchers uncovered disease-linked loci both within and beyond the HLA region.

Researchers identified several immune-related genes in a GWAS that included more than 2,200 COVID-19 patients treated in UK intensive care units.

The study, which focused on Europeans, also highlighted a role for enhancers during embryonic development in determining facial features.

In PLOS this week: somatic mutation patterns of glioblastomas among Lebanese patients, phenome-wide study using UK Biobank data, and more.

Exome array-wide association and rare variant-focused genome-wide association meta-analyses led to 87 rare variants with ties to one or more blood pressure traits.

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Politico notes that the Biden Administration has not yet nominated a permanent Food and Drug Administration commissioner. 

Anthony Fauci also informed the World Health Organization executive board that the US would be joining the COVAX initiative, according to CNBC.

A new preprint suggests some SARS-CoV-2 variants could affect the effectiveness of current vaccines, the Associated Press reports.

In Nature this week: Australian lungfish provides details on the movement of vertebrate life from water to land, and more.