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GWAS

A genome-wide meta-analysis involving more than 435,000 individuals also linked problematic alcohol use with other substance abuse and psychiatric disorders.

In animal models, loss of ALK was associated with protection from obesity, even when the animals were on a high-fat diet.

A genome-wide association study on hundreds of thousands of women with or without breast cancer implicated 32 new risk loci, including sites associated with specific subtypes.

In Nature this week: missense variant linked to decreased height among Peruvians, genetic basis of sex-biased vulnerability to certain disorders, and more.

The variant also appears to be under positive selection and is more common among coastal Peruvians.

A GWAS that incorporated magnetic resonance imaging data for UK Biobank participants led to 45 previously undetected risk loci related to dilated cardiomyopathy.

With genome sequences for nearly 900 individuals with primary immunodeficiency, researchers identified candidate genes and common variant contributors.

The researchers said the findings underscore the need to study disease variants in a range of ancestral backgrounds.

In Nature this week: combining genome-wide association and transcriptome study data homes in on cells involved in brain disorders, and more.

Researchers combined genome-wide association and transcriptome study data to uncover cell types affected by complex brain disorders, including Parkinson's disease.

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New analyses indicate female researchers are publishing less during the coronavirus pandemic than male researchers, according to Nature News.

A study suggests people with the ApoE e4 genotype may be more likely to have severe COVID-19 than those with other genotypes, the Guardian says.

Direct-to-consumer genetic testing companies are searching for a genetic reason for why some people, but not others, become gravely ill with COVID-19, the Detroit Free Press reports.

In PNAS this week: forward genetics-base analysis of retinal development, interactions of T cell receptors with neoantigens in colorectal cancer, and more.