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GWAS

A genome-wide association study focused on hundreds of immune cell features identified genetic risk variants involved in several autoimmune conditions.

In PLOS this week: functional effect of adiponectin-linked variants, sequencing reveals regional differences among Swedes, and more.

Using genome-wide association study, cell line, organoid, and other data, researchers tracked down polygenic contributors to drug-induced liver injury in hepatocytes.

A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.

The analysis drew on thousands of cases and controls and suggested a role for an autoimmune factor in penicillin allergies. 

Researchers in the UK are building a database of dog DNA to uncover inherited disease among dog breeds with low numbers, Wired UK reports.

Duality will apply homomorphic encryption to data from multiple sources to train machine learning while safeguarding the privacy of individual patients.

Phenotypic clustering identified distinct forms of PCOS with specific gene variants, providing a promising strategy for enhancing the treatment of this syndrome.

In PLOS this week: FANCJ mutations linked to increased sensitivity to certain drugs, host genetic factors influence wound microbiomes, and more.

Using array-based genotyping profiles for COVID-19 cases and controls, researchers identified loci on chromosomes 3 and 9 that are linked to cases with respiratory failure.

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Novavax has begun a phase III trial of its SARS-CoV-2 vaccine, according to the New York Times.

Vox reports that the Trump Administration may limit student visas for individuals from some countries to two years.

The governor of New York says the state will conduct its own review of any SARS-CoV-2 vaccine, NPR reports.

This week in Science: Neanderthal Y chromosomes replaced by Homo sapiens Y chromosomes, and more.