GWAS
Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets
Starting with a large GWAS, researchers incorporated chromatin accessibility data and other clues to find key variants, immune cell types, and treatment targets.
Novel Locus Tied to Rheumatic Heart Disease in Black Africans
A lack of an independent cohort limited the researchers' ability to replicate their finding and underscored the need for better representation of Africans in research.
GWAS Across Ancestries Uncovers Novel Genetic Loci Linked to Glycemic Traits
The researchers estimated that if their analysis had only focused on individuals of European descent, they would have missed two dozen novel loci.
Large-Scale Depression Genetic Study Uncovers Additional Risk Loci, Ties to Potential Drugs
The analysis drew upon data from the Million Veteran Program and other large-scale efforts and underscores the genetic complexity of depression.
Bipolar Disorder GWAS Meta-Analysis Points to Potential Treatment Targets
Researchers identified 64 risk loci in a genome-wide association study meta-analysis that included almost 42,000 individuals with bipolar disorder.