A large genome-wide association in breast cancer cases and controls from Japan led to common variants linked to disease risk at two new and nine known risk loci.
Researchers documented population structure, ancestry patterns, trait associations, and more with variants found in the genomes of more than 6,400 Ugandans.
Researchers have tied nearly 200 candidate genes, including ones involved in neurodevelopment, apoptosis, and inflammation, to the volume of brain structures.
According to simulations and a study of large families presented at ASHG this week, current polygenic scores cannot accurately predict complex human traits.
The search uncovered two post-traumatic stress disorder loci in Europeans and a third in individuals with African ancestry, highlighting immune- and brain-related genes.
The results of the study, which involved more than 47,000 MS patients and 68,000 unaffected controls, explain almost half of the disease's estimated heritability.
Dan Rather, the former CBS Evening News anchor and executive producer of a new documentary, writes at the Guardian that everyone needs to know about CRISPR.
In PNAS this week: analysis of FOXA1 upregulation in ER-positive breast cancer, gene editing to correct recessive dystrophic epidermolysis bullosa, and more.
