genetic risk variants GWAS With Higher Genetic Diversity Lead to More Accurate Use of Polygenic Risk Scores Increasing diversity in large studies results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction. Variant Identified in Amish Population Appears to Protect From Cardiovascular Disease A rare missense variant in the enzyme-coding gene B4GALT1 is linked to lower coronary artery disease risk and reduced blood LDL cholesterol levels. Diabetes Subtypes Stem From Distinct Genetic Contributors, Study Suggests Researchers described five diabetes clusters with specific clinical features that corresponded to different genetic contributors, genetic risk scores, and family history patterns. SUPER Psychosis Study Presented at ASHG Digs Into Relationships of Rare Variants, Phenotypes Using sequence data for tens of thousands of psychotic disease cases and controls, researchers have begun unearthing specific phenotypes linked to rare variants. Germline Cancer Risk Genes May Hold Rhabdomyosarcoma Survival Clues, Study Suggests Research presented at ASHG suggested that germline cancer susceptibility profiling may help to predict survival outcomes for a subset of rhabdomyosarcoma cases. Oct 20, 2021 New Rare Disease Risk Loci Uncovered With 23andMe Participant Data Oct 8, 2021 Vertigo Risk Variant Set Points to Related Inner Ear Processes Sep 30, 2021 Multi-Ancestry GWAS Leads to Loci Linked to Hundreds of Human Phenotypes Sep 28, 2021 New Leukocyte-Linked Loci Uncovered With Multi-Ancestry Genomes Sep 14, 2021 Centenarian Exome Analysis Points to Conserved Longevity Pathways Sep 7, 2021 Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis Sep 3, 2021 Consortium Catalogs Variants Affecting Blood Gene Expression Aug 26, 2021 Osteoarthritis GWAS Leads to Key Genes, Treatment Targets Aug 26, 2021 Risk Related to Genetic Contributors Can Decline With Age for Some Common Diseases Aug 20, 2021 Pediatric Cardiovascular Genetic Testing Should Be Individualized, Multidisciplinary, Says AHA Aug 18, 2021 Helix Study Identifies Additional Genes for Population Genetic Screening Premium Aug 6, 2021 Breast Cancer Genetic Risk Modified by Corticosteroid Use Jul 28, 2021 Testosterone-Related Genetic Variants Don't Influence Socioeconomic Status, Study Finds Jul 28, 2021 Polygenic Cancer Risk Score Mitigated by Healthy Lifestyle, Study Suggests Jul 22, 2021 Multi-Ethnic Migraine GWAS Uncovers Risk Loci Specific to Sex, Ancestry Jul 15, 2021 Germline Loss-of-Function Variants in ATM Gene May Contribute to Melanoma Predisposition Jul 13, 2021 Gastric Cancer Cases Frequently Harbor Genetic Risk Variants, Suggesting Germline Testing Jun 17, 2021 GWAS Reveals New Loci Linked to Brain White Matter Microstructure May 27, 2021 Large-Scale Depression Genetic Study Uncovers Additional Risk Loci, Ties to Potential Drugs May 17, 2021 Bipolar Disorder GWAS Meta-Analysis Points to Potential Treatment Targets Load More Breaking News Pediatric Cardiomyopathy Exome Sequencing Study Suggests More Disease Genes to be Found People in the News: New Appointments at Helix, Pacific Biosciences, SomaLogic, More New Products Posted to GenomeWeb: Amoy Diagnostics, Akoya Biosciences, Congenica, Lucence In Brief This Week: BGI, Gencove, Cepheid, Biocartis, Biognosys, Co-Diagnostics, More Florida Lab Owner Pleads Guilty to $6.9M COVID-19 False Billing Scheme Pacific Biosciences Outlines Progress on Short-Read Sequencing at JPM, Partners With Canexia Health The Scan Close Panel Vote on Califf Nomination The New York Times reports there was a close committee vote to advance the nomination of Robert Califf to lead the US Food and Drug Administration to the full Senate. Task Force Reports on Scientific Integrity Nature News writes that that a new task force report recommends that the US establish a cross-agency scientific integrity council. Across the Hall Genetic testing, closed-circuit cameras, and more show how a traveler, without any contact, infected others at a New Zealand quarantine facility, CNN reports. Science Paper Examines Influence of Chromatin Modifications on Obsessive-Compulsive Disorder In Science this week: genes regulating chromatin modification may contribute to OCD risk.