genetic risk variants
Centenarian Exome Analysis Points to Conserved Longevity Pathways
Researchers found rare coding variants in conserved pathways that appear to be associated with longevity and potentially protect against aging.
Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis
The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily.
Consortium Catalogs Variants Affecting Blood Gene Expression
Members of the eQTLGen Consortium turned to data for almost 31,700 individuals to define local and distant expression quantitative trait loci affecting gene expression in the blood.
Osteoarthritis GWAS Leads to Key Genes, Treatment Targets
With a genome-wide association study and functional follow-up analyses, investigators saw 100 osteoarthritis-related loci including variants in potentially targetable genes and pathways.
Risk Related to Genetic Contributors Can Decline With Age for Some Common Diseases
Analyses of UK Biobank data indicated that the relative risk for some common diseases may be more pronounced for younger individuals carrying disease-related genetic factors.