genetic risk variants Centenarian Exome Analysis Points to Conserved Longevity Pathways Researchers found rare coding variants in conserved pathways that appear to be associated with longevity and potentially protect against aging. Polygenic Risk Score Addition Does Not Improve Models Predicting Schizophrenia Prognosis The findings highlight the need for polygenic risk scores to not only be predictive but also provide additional information that cannot be captured elsewhere more easily. Consortium Catalogs Variants Affecting Blood Gene Expression Members of the eQTLGen Consortium turned to data for almost 31,700 individuals to define local and distant expression quantitative trait loci affecting gene expression in the blood. Osteoarthritis GWAS Leads to Key Genes, Treatment Targets With a genome-wide association study and functional follow-up analyses, investigators saw 100 osteoarthritis-related loci including variants in potentially targetable genes and pathways. Risk Related to Genetic Contributors Can Decline With Age for Some Common Diseases Analyses of UK Biobank data indicated that the relative risk for some common diseases may be more pronounced for younger individuals carrying disease-related genetic factors. Aug 20, 2021 Pediatric Cardiovascular Genetic Testing Should Be Individualized, Multidisciplinary, Says AHA Aug 18, 2021 Helix Study Identifies Additional Genes for Population Genetic Screening Premium Aug 6, 2021 Breast Cancer Genetic Risk Modified by Corticosteroid Use Jul 28, 2021 Testosterone-Related Genetic Variants Don't Influence Socioeconomic Status, Study Finds Jul 28, 2021 Polygenic Cancer Risk Score Mitigated by Healthy Lifestyle, Study Suggests Jul 22, 2021 Multi-Ethnic Migraine GWAS Uncovers Risk Loci Specific to Sex, Ancestry Jul 15, 2021 Germline Loss-of-Function Variants in ATM Gene May Contribute to Melanoma Predisposition Jul 13, 2021 Gastric Cancer Cases Frequently Harbor Genetic Risk Variants, Suggesting Germline Testing Jun 17, 2021 GWAS Reveals New Loci Linked to Brain White Matter Microstructure May 27, 2021 Large-Scale Depression Genetic Study Uncovers Additional Risk Loci, Ties to Potential Drugs May 17, 2021 Bipolar Disorder GWAS Meta-Analysis Points to Potential Treatment Targets Apr 22, 2021 23andMe Team Sees Genetic, Nongenetic Contributors to COVID-19 Risk in Trans-Ancestry Study Apr 21, 2021 Red Blood Cell Traits Linked to New Loci With Whole-Genome Sequencing Data Apr 16, 2021 Team Tracks Genetic Factors Linked to Severe COVID-19, Other Viral Infections in Children Apr 15, 2021 At ACMG, Mechanism for Common Breast Cancer Locus Proposed From Functional Analysis Apr 7, 2021 Preconception Genetic Testing Firm Orchid Raises $4.5M in Seed Funding Apr 2, 2021 Alzheimer's Disease Genomes Lead to Novel Loci Involved in Synaptic Function Mar 30, 2021 Renal Cell Carcinoma Risk Gene Representation Can Vary With Ancestry Mar 23, 2021 Finnish Cardiometabolic Study Uncovers Strong Effect of Structural Variants Mar 22, 2021 Ultra-Rare Genetic Variants in Protocadherin Gene Linked to Schizophrenia Load More Breaking News Ancient DNA Analysis Highlights Three Ancestral Populations in Japan FDA Warns of Potential False Positives With Abbott SARS-CoV-2 Molecular Tests New Products Posted to GenomeWeb: Oxford Nanopore, Beckman Coulter, Thermo Fisher Scientific, More People in the News: New Appointments at Sema4, NHGRI, Dante Labs, Ancestry, More Thermo Fisher Scientific Expects 12 Percent Revenue Growth in 2022 In Brief This Week: Myriad Genetics, Danaher, Co-Diagnostics, and More The Scan For Those Thick Tiger Stripes Tigers in India with thick stripes harbor a genetic change, as Gizmodo reports. High GABA Tomatoes The Japan News reports that genome-edited tomatoes with higher GABA levels are now for sale in Japan. Approach for Inclusivity and Diversity A National Human Genome Research Institute team calls for the field to "adopt diversity as an ethos." Science Papers on Tumors Immune System Evasion; Drivers of Genomic Instability, Inflammation In Science this week: study of how tumors evade the adaptive immune system, and more.