genetic risk variants Geisinger MyCode Study Reveals Prevalence of Somatic Variants Linked to Rare Syndrome Using exome sequence data for more than 163,000 Geisinger MyCode participants, researchers looked for variants in UBA1 that have been linked to VEXAS syndrome. Type 2 Diabetes Mechanisms, Risk Genes Identified in GWAS Meta-Analysis Researchers uncovered candidate risk genes and potential mechanisms and conducted further analyses of proinsulin-associated risk loci. Sarcoma Susceptibility Traced to Telomere Function, Mitotic Pathways A search for rare sarcoma-related germline variants led to centromere and shelterin genes involved in mitotic function and telomere regulation, respectively. Cochlear Implant Outcomes Linked to Type of Genetic Diagnosis for Childhood Hearing Loss Data from more than 400 families affected by childhood-onset hearing loss indicated that specific genes and variants can provide prognostic clues, including success of cochlear implants. Varicose Vein GWAS Points to Vascular Risk Loci, Potential Treatment Targets Starting with a multi-ancestry genome-wide association study, researchers unearthed varicose vein-related variants, along with related traits and treatment targets. Dec 20, 2022 Multiomic Study Points to New Colorectal Cancer Risk Contributors Dec 16, 2022 Study Finds Genetic Roots of Brown Coloring in Black Bears Dec 14, 2022 Study Links Maternal Mental Illness-Related Variants to Perinatal Risk Factors For Offspring Dec 7, 2022 Tobacco, Alcohol Use Contributors Uncovered With Multi-Ancestry GWAS Dec 5, 2022 Cross-Trait Meta-Analysis Explores Potential Pleiotropy Across Psychiatric Conditions Nov 30, 2022 Clonal Hematopoiesis Linked to Common, Rare Genetic Variants Nov 21, 2022 New Osteoarthritis Genetic Risk Loci Uncovered in Multi-Ancestry Analyses Nov 17, 2022 Non-Random Mating May Exaggerate Findings of Pleiotropy in Population Genetic Studies Nov 3, 2022 Meta-Analyses Hint at Severe COVID-19 Risk Factors, Ties to Autoimmune Disease Nov 1, 2022 Epilepsy Management Often Shifts After Multigene Panel Testing, Study Finds Oct 28, 2022 Complex Trait-Related CNVs Unearthed Using Haplotype-Informed Approach Oct 25, 2022 Diabetes Polygenic Risk Score Performance Improved by Addition of Rare Variants Oct 24, 2022 Liver Disease Multiomic Analysis Reveals Detection Clues, Points to Treatment Strategies Oct 20, 2022 Dyslexia GWAS Leads to Dozens of Risk Loci, Polygenic Risk Score Oct 18, 2022 Hip Fracture GWAS, Mendelian Randomization Reveal Risk Loci Oct 7, 2022 Team Untangles Mechanism Behind Noncoding Glioma Risk Variant Oct 6, 2022 Breast Cancer Risk Contributors, Remaining Gaps Found With Familial Analyses Oct 4, 2022 Sequencing Data Helps Elucidate Blood Pressure Ties to Rare Sodium Channel Mutations Sep 30, 2022 Stroke Risk Contributors, Treatment Targets Uncovered in Cross-Ancestry GWAS Sep 19, 2022 Extrachromosomal DNA Appears to Boost Cancer Adaptability, Impact Drug Response Load More Breaking News New Products Posted to GenomeWeb: Qiagen, Thermo Fisher, Bionano Genomics, BillionToOne, More People in the News at Illumina Ventures, Element Biosciences, Epigenomics, Exagen, More Genomic Approaches Boost Rare Disease Diagnoses in Middle Eastern Patient Population GeneDx to Raise $150M in Public and Direct Stock Offerings In Brief This Week: T2 Biosystems, Novacyt, OpGen, Dante Genomics, Nautilus Biotechnology, More The Scan Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups. Genome-Wide Analysis Sheds Light on Genetics of ADHD A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder. MicroRNA Cotargeting Linked to Lupus A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus. Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.