gene regulation

Researchers used array-based DNA methylation data to quantify methylation levels in almost 1,500 identical or non-identical twins.

In Nucleic Acids Research this week: chromatin accessibility profiles in P. falciparum during development, transcriptional start sites and regulatory patterns in A. baumannii, and more.

Researchers used brain expression data from mice with well-documented sleep traits to identify gene networks that overlap with those in human depression.

Researchers found that individuals with unexplained neurodevelopmental disorders and congenital anomalies had an enrichment of de novo epivariations.

This Week in PLOS

In PLOS this week: cancer predisposition among Cowden/Cowden-like and Bannayan-Riley-Ruvalcaba syndrome patients, and more.

Researchers found that children with autism are more likely to inherit cis-regulatory structural variants from their fathers than their unaffected siblings.

Researchers have done single-cell RNA sequencing on hundreds of Plasmodium falciparum or P. berghei isolates to track gene activity involved in infection cycles.

In cases lacking explanatory protein-coding changes, researchers saw an uptick in de novo mutations in conserved, non-coding regulatory elements.

Under an NIH grant, the San Diego-based firm is developing a kit for studying RNA-binding proteins that it plans to launch by early 2019.

Researchers discovered thousands of candidate functional elements by searching diverse mammalian genomes for regions of accelerated evolution within highly conserved sites.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.