gene regulation
Consortium Catalogs Variants Affecting Blood Gene Expression
Members of the eQTLGen Consortium turned to data for almost 31,700 individuals to define local and distant expression quantitative trait loci affecting gene expression in the blood.
Fast-Evolving Human Genome Sequences Found to Have Brain-Related Regulatory Roles
An integrated analysis that spanned thousands of human accelerated regions suggested they harbor regulatory elements with roles in human brain development.
Genome Biology Papers on Death Camp Forensics, Cancer Co-Regulation, Single-Cell Splice Junctions
In Genome Biology this week: genetic evidence finds death camp remains belonged to members of Ashkenazi Jewish population, gene co-regulation of chromatin in cancer, and more.
Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets
Starting with a large GWAS, researchers incorporated chromatin accessibility data and other clues to find key variants, immune cell types, and treatment targets.
Blood Cancer Genetic Risk Loci Found in Retriever Dogs
Using a genome-wide association study and multiomic follow up, investigators tracked down genes involved in histiocytic sarcoma in flat-coated retrievers.