gene regulation
Female-Specific Fat Distribution Gene, Regulatory Variant Emerge from Gene Expression Study
With transcriptome-wide association studies of BMI and waist-to-hip ratio adjusted for BMI, researchers began to untangle the genetics of fat distribution.
New Cell Culture, Analysis Approach Helps Explain Differences in Zika Virus Susceptibility
Researchers profiled "cell villages" comprised of neural cell progenitor cells from several donors with single-cell RNA-seq, WGS, and related computational approaches.
Ewing Sarcoma Risk Locus Analysis Sheds Light on Cancer's Formation
Analyzing a chromosome 6 risk locus by long-read sequencing, researchers saw a combination of germline and somatic alterations interacting in the development of Ewing sarcoma.
Circadian Gene Expression Variation Across Tissue Types May Offer Aging, Disease Clues
With a new computational approach, researchers profiled gene expression rhythms in dozens of tissues from more than 900 individuals for the Genotype-Tissue Expression project.
Denisovan DNA Detected in Papuan Immune Gene Regulatory Regions
Researchers mapped archaic and non-archaic variants in 56 Papuan genome sequences, tracking down Denisovan variants at regulatory elements linked to cells with immune roles.