gene regulation
ALL Genomes Marked by High DNA Methylation Levels
Starting with samples from 82 pediatric cases of B-cell or T-cell acute lymphoblastic leukemia, researchers found widespread hypermethylation across ALL genomes.
Single-Cell Transcriptome Resource From Human Cell Atlas Team Yields Immune, Disease Insights
Researchers tallied expression features across hundreds of cell types with single-cell or -nucleus sequencing on hundreds of thousands of cells from numerous individuals.
Single-Cell Sequencing Study Uncovers Blood Cell Type-Specific Features
Single-cell RNA sequencing and other approaches helped characterize systemic lupus erythematosus immune features, including cell type-specific expression profiles.
Researchers Generate Catalog of Noncoding Somatic Mutations in Cancer Genomes
The study included mutations in regulatory regions that could be driver mutations.
T2T Consortium Publishes Early Findings From Complete Human Genome Assembly
In a series of studies, investigators outlined methods used to produce a telomere-to-telomere version of the human genome, while touching on applications of the assembly.