gene regulation

Investigators compared RNA sequence data in heart samples from individuals with dilated cardiomyopathy and samples from healthy transplant donor hearts.

Researchers found 7 percent of mutations in children's DNA could be traced to postzygotic mosaic mutations present early in their parents' embryonic development.

Researchers identified shifts in regulatory features and enhanced NOTCH signaling pathway activation in prostate tumors containing a TMPRSS2-ERG2 gene fusion.

Researchers outlined the "nicking enzyme-assisted sequencing" (NicE-seq) protocol and presented results from proof-of-principal open chromatin profiling experiments.

This Week in PNAS

In PNAS this week: statistical method for gene regulation evaluation, sea urchin gene regulatory networks, and more.

A method called genome architecture mapping, or GAM, brings together deep DNA sequencing and laser microdissected slices of individuals cells in a tissue sample.

At the Plant and Animal Genomes conference, a Cold Spring Harbor Lab researcher provided information on an upcoming study of maize regulatory elements.

Members of the International Human Epigenome Consortium published several new studies describing advances in understanding immune system regulation.

Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.

This Week in Nature

In Nature this week: genome of a Korean individual, genomic study of ancient settlers of Vanuatu and Tonga, and more.

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The Seattle Times writes that pharmacogenomics testing can help choose medications that may work best for people with depression.

Researchers report that deleting one gene from butterflies affects their wing coloration patterns, according to the Washington Post.

In PNAS this week: genome sequencing of weevil symbionts, retinoid X receptor deletion in lung cancer metastasis, and more.

Sequencing could help combat foodborne illnesses, according to a blog post by Food and Drug Administration officials.