gene regulation Blood Cancer Genetic Risk Loci Found in Retriever Dogs Using a genome-wide association study and multiomic follow up, investigators tracked down genes involved in histiocytic sarcoma in flat-coated retrievers. Fetal Hemoglobin Gene Regulation Study Points to Potential Therapeutic Targets Regulatory elements revealed in the study could potentially be targeted by base editors to treat conditions like sickle cell disease. Red Blood Cell Traits Linked to New Loci With Whole-Genome Sequencing Data Using sequencing data for almost 62,700 individuals, researchers found new coding and non-coding variants associated with seven quantitative red blood cell features. At ACMG, Mechanism for Common Breast Cancer Locus Proposed From Functional Analysis With regulatory and functional data, investigators saw a possible tumor suppressor role for a gene flagged by common variants in a breast cancer GWAS. Induced Pluripotent Stem Cells Show Potential for Finding New Regulatory Variants Two studies identified common and rare regulatory variants in iPSC lines, including those with ties to disease or differentiation. Feb 24, 2021 Proteogenomic Study Expands Catalog of Cell Cycle Players Feb 3, 2021 Human Epigenome Map Reveals New Insights Into Genetic Loci for Traits, Diseases Jan 5, 2021 Single-Cell Sequencing Reveals Immune Contributors to Exacerbated Asthma in Mouse Model Dec 11, 2020 COVID-19 GWAS Leads to Immune Genes Linked to Severe Disease, Treatment Targets Dec 8, 2020 Single-Cell Transcriptome Study Links Gut Development, Pediatric Crohn's Disease Dec 7, 2020 Neuroblastoma Super Enhancer Profiles Pinpoint Four Epigenetic Subtypes Oct 14, 2020 Epigenomic Study of Brain Development Uncovers Cell Type-Specific Regulatory Programs Sep 10, 2020 Longitudinal Irritable Bowel Syndrome Omics Study Points to Possible Treatment Target Jul 20, 2020 Prostate Cancer Metastasis Linked to Development-Related Epigenetic Shift Jul 13, 2020 Metastatic Prostate Cancer Methylation Analysis Reveals Subtype, Ties to Driver Genes Jul 9, 2020 Integrated Proteomic Papers Define Lung Cancer Features Across Populations, Smoking Histories Jun 23, 2020 Tissue Network Analysis Points to Significant Sex-Related Regulatory Differences Jun 9, 2020 Glioblastoma Genomes Point to Non-Coding Driver Mutations May 7, 2020 Primary Immunodeficiency Study Highlights Monogenic, Common Variant Disease Contributors Apr 16, 2020 Human Tumor Atlas Network Team Shares Strategy for Tracking Tumor Transitions Mar 9, 2020 Integrated Genomic Analysis Highlights Potential Strategy for Overcoming Some ALL Resistance Feb 14, 2020 Genetic Study of Snoring Highlights Ties to Diverse Traits, Behaviors Feb 12, 2020 Schizophrenia Associated With Blood DNA Methylation Signature Jan 31, 2020 Single-Cell Sequencing Study Suggests Antioxidant Pathway Role in Female Fertility Declines Jan 21, 2020 Urinary Metabolite GWAS Leads to Risk Variants, Potential Markers of Kidney Disease Load More Breaking News Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy Space Radiation Shows Limited Effects on Mammalian Sperm DNA, Fertility Bluestar Genomics Sues Former Consultant, Ludwig Institute for Cancer Research Over IP Ownership New Products Posted to GenomeWeb: 10x Genomics, Swift Biosciences, Agilent Technologies, More In Brief This Week: Quantum-Si, TGen, Yale, and More People in the News: New Appointments at Invitae, PGDx, Oxford Nanopore, PacBio, More The Scan Fertility Fraud Found Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today. Ties Between Vigorous Exercise, ALS in Genetically At-Risk People Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports. Test Warning The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK. Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.