gene regulation
Blood Cancer Genetic Risk Loci Found in Retriever Dogs
Using a genome-wide association study and multiomic follow up, investigators tracked down genes involved in histiocytic sarcoma in flat-coated retrievers.
Fetal Hemoglobin Gene Regulation Study Points to Potential Therapeutic Targets
Regulatory elements revealed in the study could potentially be targeted by base editors to treat conditions like sickle cell disease.
Red Blood Cell Traits Linked to New Loci With Whole-Genome Sequencing Data
Using sequencing data for almost 62,700 individuals, researchers found new coding and non-coding variants associated with seven quantitative red blood cell features.
At ACMG, Mechanism for Common Breast Cancer Locus Proposed From Functional Analysis
With regulatory and functional data, investigators saw a possible tumor suppressor role for a gene flagged by common variants in a breast cancer GWAS.
Induced Pluripotent Stem Cells Show Potential for Finding New Regulatory Variants
Two studies identified common and rare regulatory variants in iPSC lines, including those with ties to disease or differentiation.