FLT3 Invivoscribe, Kronos Bio Partner on Companion Diagnostic Test for Leukemia Drug The companion diagnostic assay would identify mutations in the NPM1 gene, which Kronos Bio is targeting with its investigational drug entospletinib. Japanese Regulators Approve Invivoscribe Assay as CDx for Daiichi Sankyo AML Drug The LeukoStrat CDx FLT3 Mutation Assay can now be used in Japan as the CDx for quizartinib for the treatment of FLT3-ITD positive relapsed or refractory AML. Single-Cell Sequencing Proves Useful for Tracking Drug-Resistant AML Mutation Progression Premium Researchers used Mission Bio's Tapestri assay to identify and monitor the evolution of cancer mutations in acute myeloid leukemia in response to targeted treatment. FLT3 Inhibitor Treatment Improves Survival in Relapsed, Refractory AML Patients With Mutations Results from the phase 3 ADMIRAL trial were announced during the American Association for Cancer Research annual meeting. First Veterans Affairs MDx Lab Launches NGS-Based Cancer Panel; Others to Follow Premium The VA decided to bring this testing in house to streamline and standardize the process for doctors and gauge markers that are relevant to the veteran population. Nov 28, 2018 Invivoscribe CDx Assay Gets Expanded FDA Approval Alongside Astellas AML Drug Nov 27, 2018 Invivoscribe Submits FLT3 Mutation CDx Assay to FDA Nov 19, 2018 Invivoscribe Submits FLT3 Mutation Assay CDx to Japanese Regulators Sep 27, 2018 Invivoscribe Receives Regulatory Approval for FLT3 Mutation Assay in Japan Jun 26, 2018 Rare Immune Cells, Cytokine May Predict Response to Cancer Immunotherapy May 8, 2018 Invivoscribe Submits Regulatory Applications in Japan, US for AML CDx Feb 6, 2018 Sophia Genetics Gains CE-IVD Mark for Leukemia Assay Aug 1, 2017 Invivoscribe Garners CE Mark for LeukoStrat CDx FLT3 Mutation Assay Apr 28, 2017 FDA Approves Rx/Dx Combination for Acute Myeloid Leukemia Jan 31, 2017 Invivoscribe, Thermo Fisher to Develop FLT3 Mutation, Clonality Assay Kits Mar 20, 2015 Genection's AML Panel First of Several NGS-based Dx Tests it Plans to Bring Through FDA Clearance Premium Nov 19, 2014 Dana-Farber, Brigham and Women's Develop NGS Panel for Rapid Diagnosis of Hematologic Cancers Premium Dec 14, 2011 Plexxikon Launching Phase I/II Trial for PLX3397 in AML Patients with Flt3 Mutations Premium Feb 23, 2011 Novartis, Invivoscribe to Develop Companion Test for Acute Myeloid Leukemia Rx Midostaurin Premium Breaking News CDC Provides $90M in Funding to Establish Pathogen Genomics Network People in the News at 23andMe, DNAnexus, Next Gen Diagnostics, More Study Finds Metabolomic States Informing Common Disease Risk New Products Posted to GenomeWeb: Allelica, Vizgen, Codex DNA, More In Brief This Week: Thermo Fisher Scientific, Exact Sciences, T2 Biosystems, Helix, More The Scan Mosquitos Genetically Modified to Prevent Malaria Spread A gene drive approach could be used to render mosquitos unable to spread malaria, researchers report in Science Advances. Gut Microbiomes Allow Bears to Grow to Similar Sizes Despite Differing Diets Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods. Finding Safe Harbor in the Human Genome In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function. New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.