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evolutionary biology

Using haplotype profiling, phylogenetics, and other analyses, researchers retraced sickle allele emergence to a single event occurring roughly 7,300 years ago.

Researchers discovered thousands of candidate functional elements by searching diverse mammalian genomes for regions of accelerated evolution within highly conserved sites.

Research on phages in CRISPR-Cas9-containing Escherichia coli indicated that pressure exerted by the bacterial defense system can boost phage mutation frequency.

In PLOS this week: ramifications of sexual recombination in bacteria, Mycobacterium leprae genome sequences, and more.

Still Evolving

A new paper in PNAS finds that people are still evolving, but with increased pressure on weight and decreased pressure on intelligence.

Tasmanian tiger/thylacine/Tasmanian wolf

A genomic analysis of the Tasmanian tiger pointed to early genetic diversity declines in the species, while offering clues to convergent canid features.

In Cell this week: integrated genomic analysis of adult soft tissue sarcoma, positive selection has greater role in cancer than negative selection, and more.

In PNAS this week: effector proteins contributing to Legionnaires' disease virulence, proteomic analysis of transition to quiescence, and more.

Batang Toru orangutan

Using genome sequencing, phylogenomics, morphological analyses, and more, investigators defined a rare new orangutan species dubbed Pongo tapanuliensis.

University of Chicago researchers combined epidemiological and viral gene evolution data to refine influenza modeling.

Pages

In a cartoon, Vox explores the lack of women among this year's winners of the Nobel Prize.

Science reports a new US defense bill would establish two groups aimed at combating foreign influence on research. 

Nature Biotechnology discusses promising early results from two clinical trials of CRISPR-based therapy for β-thalassemia and sickle cell disease.

In Cell this week: analysis of tissue clones, metagenomic studies of ocean water samples, and more.