evolution

A phylogenetic analysis that included multiple samples per patient suggests overlapping driver mutations make their way into multiple metastases in each patient.

Brown bear.

By sequencing four ancient cave bears and comparing them to other bear species, researchers retraced historical admixture of cave bears and brown bears.

In Genome Biology this week: coding variants linked to cardiac conduction, comparison of two dozen differential gene expression analysis pipelines, and more.

A Stony Brook University-led team re-analyzed the FOXP2 gene for signs of selection using a larger, more diverse cohort, but were unable to find any.

The system, called EvolvR, can continuously diversify all nucleotides within a tunable window at user-defined loci using CRISPR-guided nickases.

Using genome sequencing and phylogenetics, researchers have shown that the industrial yeast Pichia kudriavzevii is genetically the same species as Candida krusei.

From infant skeletal remains going back hundreds of years, a team produced three Treponema pallidum genomes, representing both syphilis- and yaws-causing sub-species.

This Week in PLOS

In PLOS this week: comparison of commercial bisulfite kits, new method to predict essential proteins, and more

Got Big Brains

Researchers have uncovered a trio of human-specific genes that seem to govern people's large brain size, Reuters reports.

Velociraptor mongoliensis

Using bioinformatic and molecular cytogenetic approaches, researchers retraced ancestral "diapsid" reptile genome patterns from extant bird and reptile genomes.

Pages

Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.