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EGFR Biomarkers

News and reporting on EGFR biomarkers.

The clinical collaboration will evaluate Trovagene's technology in clinical studies for detecting genetic mutations associated with targeted drug resistance.

As AstraZeneca takes steps to reintroduce the EGFR-targeted NSCLC drug in the US, Qiagen will develop a tissue-based molecular CDx to accompany the launch.

The scientific organizations are revisiting the topic of molecular testing for lung cancer patients just a year and a half after releasing the initial guidelines. 

The company, whose technology enables the selective amplification of mutant DNA, will use the financing to ramp up its commercialization work and build its product portfolio.

The collaboration will explore the clinical utility of Trovagene's platform for detecting and monitoring EGFR mutations in lung cancer patients. 

A study comparing DNA extracted from standardized blocks of FFPE showed variability among experienced molecular pathology labs.

New survival data suggest that patients with del19 mutations should receive Gilotrif as their top option and that researchers should no longer clump different EGFR-mutated subpopulations together in research, lead study investigator Lecia Sequist said.

Originally published Sept. 25.
NEW YORK (GenomeWeb) – The National Cancer Institute this week kicked off its exceptional responders program, in which researchers will sequence tumor tissue from patients who have had an outlier response to investigational treatments.

NEW YORK (GenomeWeb) – The recent lawsuit filed by Esoterix Genetic Laboratories against Qiagen over an alleged breached licensing agreement covering EGFR testing may be a message to other labs who have sold tests without a license.

NEW YORK (GenomeWeb) — Researchers from several European institutions working with AstraZeneca have published a study demonstrating that measuring EGFR mutations from circulating tumor DNA compares favorably to tissue-based EGFR mutation status.

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A new study catalogues the genome and evolutionary history of the oak family, UPI reports.

Dog DNA testing is a growing market, but there's still a lot of uncertainty about the accuracy of the results, the Boston Globe says.

A University of South Florida researcher is testing bone fragments to determine if they belong to Amelia Earhart.

In Cell this week: antisense Piwi-interacting RNA responses to endogenous retroviruses, proteomic patterns in hepatocellular carcinoma, and more.