EGFR inhibitors FDA Approves Foundation Medicine Assay as CDx for Certain NSCLC Therapies The FoundationOne Liquid CDx test can be used with Tarceva (erlotinib), Tagrisso (osimertinib), and Iressa (gefitinib), and other TKIs approved in the future. Repeat Biomarker Testing Informs Next Steps for Treatment-Resistant EGFR-Mutant NSCLC Patients Premium Studies at ESMO showed the importance of repeat biomarker testing to guide treatment after resistance to AstraZeneca's Tagrisso, but tissue-based testing remains a hindrance. FDA Approves FoundationOne CDx for EGFR Inhibitors to Identify EGFR Mutations in NSCLC The FoundationOne CDx test will be used to identify patients for treatment with FDA-approved EGFR inhibitors. Molecular Clonal Tracking Method Captures Lung Cancer Treatment Response, Resistance Features Using a single-cell sequencing and clonal fitness mapping method, researchers compared EGFR-mutant lung cancer cell responses to EGFR inhibition or targeted protein degradation. FDA Approves Janssen's Rybrevant, Guardant360 CDx for EGFR Exon 20-Mutated NSCLC The agency approved amivantamab for non-small cell lung cancer patients harboring EGFR exon 20 mutations, as detected by Guardant Health's blood-based test. Aug 2, 2019 Comparison of KRAS Liquid Biopsy Kits Confirms Differences at Low Mutant Allele Fraction Aug 2, 2019 Sysmex Gets Japanese Manufacturing, Marketing Approval for Colorectal Cancer Screening Assay Jul 23, 2019 China's NMPA Extends Approval for Roche Cobas EGFR Mutation Test v2 to Plasma Samples Mar 4, 2019 Colon Cancer Patients Could Benefit From HER2 EGFR Non-Response Findings, Investigators Say Premium Jun 6, 2017 New Precision Oncology Options Emerge at ASCO in First-Line EGFR-Mutated, ALK-Positive Lung Cancer Premium Mar 14, 2017 Roche EGFR Mutation Test Approved in Canada Apr 15, 2016 Expansion of Liquid Biopsy Test Sites Planned by Merck KGaA, Sysmex Premium Apr 7, 2016 Merck KGaA, Sysmex Inostics Garner CE Mark for Liquid Biopsy CRC Test Apr 4, 2016 Researchers Develop Whole-Exome Sequencing Pipeline to ID Variants, Match Patients to Drugs Premium Jan 29, 2016 AstraZeneca Shows Off Quick Uptake of CRISPR Tech in Drug Discovery Process Premium Sep 28, 2015 Roche's Cobas EGFR Assay Gets CE Mark Jul 14, 2015 Iressa Approval Grows Options for Lung Cancer Patients as AstraZeneca Re-establishes Presence Premium Jul 13, 2015 FDA Approves Qiagen's Therascreen EGFR Test as CDx for AstraZeneca NSCLC Drug Jun 4, 2015 Italian Team Uses Liquid Biopsy to Show Dynamic Nature of Tumor Response to Therapy Premium Mar 30, 2015 CAP, AMP Among Groups Jointly Issuing Colorectal Cancer Molecular Testing Draft Recommendations Mar 4, 2015 Study Shows cfDNA EGFR Mutations Linked to Tarceva Outcome in EURTAC Samples Premium Feb 18, 2015 Clovis Evaluating Sysmex Inostics Blood Assay to ID EGFR Mutations in ctDNA of NSCLC Patients Premium Dec 16, 2014 IntegraGen, PICCOLO Researchers Collaborate to Validate Metastatic Colorectal Cancer Biomarker Sep 3, 2014 EGL Lawsuit against Qiagen Could Be Warning to Labs Performing EGFR Testing Without License Premium Aug 27, 2014 Circulating DNA an Appropriate Alternative for EGFR Testing When Tissue Unavailable, Study Finds Premium Load More Breaking News Simple HealthKit Raises $8M in Series A Round Top Five Articles on GenomeWeb Last Week: Quantum-Si Layoffs, UBS Coverage Initiations, More LumiraDx Secures FDA Emergency Use Authorization, UK Approval for COVID-19, Flu Test Rarity Bioscience Raises Additional €500,000 Cancer Prognoses Informed by Module-Based Approach, Study Finds The Scan UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers. DNA Biobank Developed for French Kidney Donors, Recipients The KiT-GENIE biobank described in the European Journal of Human Genetics contains DNA samples, genotyping profiles, immune patterns, and clinical features for thousands of kidney donors or transplant recipients in Nantes, France. Cardiometabolic Disease May Have Distinct Associations With Microbial Metabolites in Blood, Gut By analyzing gut microbes in combination with related metabolites in feces and blood, researchers in Nature Communications found distinct cardiometabolic disease relationships at each site. Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency.