drug resistance

Using sequencing from 262 drug-resistant Plasmodium falciparum representatives, researchers characterized the malaria parasite resistome.

Teams studying kidney and skin cancers independently implicated SWI/SNF chromatin remodeling mutations in checkpoint blockade immunotherapy response.

Investigators used sequencing, phylogenetics, and epidemiology to retrace transmission during a 2008 outbreak of carbapenem-resistant Klebsiella pneumoniae.

A genome-wide association study meta-analysis found bipolar disorder patients with poor response to lithium have more polygenic risk factors for schizophrenia.

The researchers found that most advanced EGFR-mutant lung cancer patients harbored changes in an average of two to three other oncogenes.

A pair of papers point to potential gut microbial contributions to checkpoint blockade immunotherapy response in individuals with lung, kidney, or skin cancer.

Alterations affecting the antigen presentation-related gene B2M appeared to be over-represented in melanomas with checkpoint blockade non-response or resistance.

Using genomic data from large cancer cell line collections, investigators identified versions of spliced genes that spell better or worse drug response.

The Gaithersburg, Maryland-based firm intends to use the proceeds for general corporate purposes, including working capital and product development.