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Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.
Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.
The Klebsiella pneumoniae isolate was among one of the first such highly resistant strains reported to the CDC, which sequenced and analyzed it.
The funding will accelerate development of the firm's RaPID diagnostic platform to identify pathogens and drug resistance directly from blood.
Sequencing of typhoid fever outbreak samples in Pakistan indicates extensive drug resistance arose when a local multidrug resistance strain acquired a new plasmid.
Researchers identified and began characterizing carbapenemase-producing bacteria from wastewater samples in ICU pipes and other sites at an NIH hospital.
Genome sequences from southeast Asian Plasmodium falciparum isolates suggest resistance to a new treatment arose the same year it was introduced.
In Nature this week: genomes of two organisms that regenerate body parts, sea lamprey genome, and more.
An international team analyzed almost 6,500 Mycobacterium tuberculosis isolates from around the world to find new and known resistance mutations.
Researchers profiled cancer gene mutations, expression, protein patterns, and other features in 23 recurrent or metastatic cases of olfactory neuroblastoma.
New analyses indicate the P.1 variant found in Brazil may be able to infect people who have already had COVID-19, the New York Times reports.
According to CNBC, Novavax's CEO says its vaccine could be authorized in the US as early as May.
The US National Institutes of Health has a new initiative to address structural racism in biomedical research.
In PNAS this week: GWAS of TLV-1-associated myelopathy/tropical spastic paraparesis, analysis of twins with hypertrophic cardiomyopathy, and more.