Researchers used CRISPR-Cas9 screening assays in mouse and human cells to track down point mutations in the PARP1 gene that boost resistance to PARP inhibitor drugs.
Saturation mutagenesis of the human malaria parasite Plasmodium falciparum identified almost 2,700 essential genes during the blood stage of infection.
Sequencing of typhoid fever outbreak samples in Pakistan indicates extensive drug resistance arose when a local multidrug resistance strain acquired a new plasmid.
Researchers identified and began characterizing carbapenemase-producing bacteria from wastewater samples in ICU pipes and other sites at an NIH hospital.
Researchers profiled cancer gene mutations, expression, protein patterns, and other features in 23 recurrent or metastatic cases of olfactory neuroblastoma.
