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drug resistance

The firm launched a CE-IVD marked test for extremely drug-resistant TB and expects to incorporate the multiplexing technology in other assays.

The DeepChek-HIV assays are designed for settings running either Sanger sequencing or next-generation sequencing workflows, according to the company.

In PLOS this week: sequencing-based way to uncover drug resistance in tuberculosis bacteria, genetic population structure of mosquito vectors, and more.

A new analysis suggests hypermutation can occur in some chemotherapy-treated gliomas, producing heterogeneous, mutation-rich tumors with poor response to anti-PD-1 treatment.

Exposure to DNA-damaging cancer treatments affects mutational signatures found in advanced and metastatic cancers, with alterations possibly indicating drug resistance.

The team envisions developing an assay to guide targeted treatment for metastatic castration-resistant prostate cancer patients.   

The study suggested that ALL glucocorticoid resistance stemming from alterations that drive down CELSR2 levels might be combated with the BCL2-targeting drug venetoclax.

Blood and skin cell transcriptomes revealed a JAK-STAT signaling and human herpesvirus targets in an individual with refractory drug-induced hypersensitivity syndrome.

A missense change in a gene coding for an androgen production enzyme had apparent ties to poor lung function and reduced glucocorticoid drug response.

Using corrected TMB and other variables allowed Johns Hopkins researchers to more accurately predict response to immune checkpoint blockade in lung cancer.

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A study of families explores how children transmit SARS-CoV-2, according to the Associated Press.

US Agricultural Research Service scientists have sequenced the genome of the Asian giant hornet.

According to the Economist, pooled testing for COVID-19 could help alleviate strains on testing labs.

In Science this week: MIT researchers outline approach dubbed translatable components regression to predict treatment response among IBD patients.