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CTCs

The microfluidic chip, called the On-Q-ity Circulating Cancer Capture and Characterization Chip, or C5, uses both antibody affinity and size to filter CTCs from normal blood. In a study comparing C5 and a chip using antibody affinity alone, On-Q-ity's dual capture chip "greatly improved" capture rate over the comparator.

In recent interviews, J&J officials spoke about ongoing work to further develop its technology for circulating tumor cells to include characterization capabilities, and its new center of excellence for companion diagnostics to leverage partnerships with other diagnostic firms.

LabCorp will market the platform to biopharma researchers conducting clinical studies of oncology drugs.

The partners will develop a bench-top platform to isolate and explore the biology of rare cells at the protein, RNA, and DNA levels.

Initial unpublished data from studies employing the method, competitive allele-specific TaqMan PCR, suggest that it can detect single rare mutant alleles in up to a million wild-type sequences with a high degree of specificity.

Researchers from more than a dozen European research institutes and companies announced this week that they are working to develop lab-on-chip technology for detecting circulating tumor cells and disseminated tumor cells in blood.

The company's first test, a FISH-based assay targeting breast cancer, is planned for October and would represent its first product introduction in its 13-year history.

The startup has now raised a total of $26 million in Series A financing to support development of a biomarker-based cancer diagnostic.

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Researchers tie a variant in ADAMTS3 to breathing difficulties in dissimilar dog breeds, according to Discover's D-brief blog.

The Japan Times reports that researchers sequenced the genome of a woman who lived during the Jomon period.

Parents of children with rare genetic disease have to contend with shifts in the interpretation of genetic variants, the Wall Street Journal reports.

In Science this week: single-nucleus RNA sequencing of brain tissue from individuals with autism, and more.