ClinVar Colorado Center for Personalized Medicine Biobank Begins Returning Participant PGx Results Premium The group is mailing pharmacogenetic information back to patients, with plans to deliver genetic disease risk and carrier screening results. Developmental Disorder, Other Disease Genes Revealed by Mapping Regions Resistant to Change Researchers used exome data for more than 123,000 individuals to map "constrained coding regions," where disease-related variants are over-represented. FDA Recognizes ClinGen Database for Development of Clinical Tests The endorsement is the agency's first through the Human Variant Database Program, for which it released final guidance earlier this year. With Rehm as Chief Genomics Officer, MGH Starts Studying Utility of WGS, Plans Genomic Risk Clinic Premium To nudge genetic testing labs to share their variant data, MGH now requires that labs to which it sends tests to contribute variants to the ClinVar database. Personalis Report Highlights Challenges in Variant Annotation Premium Researchers compared three open source annotation tools, and also looked at correspondence with public databases, identifying a number of stumbling blocks. Dec 7, 2016 University of Washington Team Details Future of Family-Focused Genomic Data Sharing Platform Premium Oct 21, 2016 Illumina Makes Massive Variant Donation to ClinVar Oct 12, 2016 African-Ancestry Populations Harbor Genetic Variation, Differences Not Seen in Genomic Databases Breaking News People in the News at Pacific Biosciences, Metabolon, NeoGenomics, More New Products Posted to GenomeWeb: Tethis, Invitae, PerkinElmer, More In Brief This Week: Thermo Fisher Scientific, Bruker, Quantum-Si, BioMérieux, More Luminex Obtains CE Marking for MDx Panel to Detect Flu A/B, RSV, COVID-19 Palmetto Finalizes Positive LCD for Prostate Cancer Risk Tests Gene Expression, Histology Reveal Clues for Targeted Rheumatoid Arthritis Treatment The Scan Call for a Different Tack Experts weigh the value of recent experiments testing genetically modified pig kidneys using brain-dead individuals, according to Nature News. Wastewater Warning The New York Times reports that wastewater surveillance in some parts of the US point to a possible surge. Can't Get in the Program Due to the Northern Ireland protocol dispute, the European Union is preventing UK researchers from joining the Horizon Europe research program, the Times of London reports. Science Paper on Spatial-Controlled Genome Editing In Science this week: approach to enable a CRISPR-Cas13a-based system to be used as a cancer therapy.