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cell-free DNA

A proof-of-principle study suggests blood and saliva may contain markers for finding and following head and neck squamous cell carcinomas.

The company plans to expand its CLIA testing and complete a major study in theUS, as it moves forward to open a joint venture inChinathat will support further commercial expansion and clinical utility research.

Patent law experts said the ruling provides further clarity over what is and is not patentable within the broader molecular diagnostics field. 

The so-called '540 patent has been the focal point of a series of lawsuits between Sequenom and other NIPT firms since 2011. 

The company plans to move away from a centralized lab model to develop kits that can be used by any laboratory to perform its assays, focusing first on developing RUO kits and then clinical assay for lung cancer and more.

University of Leuven researchers reported that out of 4,000 noninvasive prenatal tests ran in prospective pregnancies, three yielded aberrant genome representations that were confirmed to be maternal cancer. 

With evidence of significant variation among consent procedures in the NIPT space, and the potential for a lack of awareness about incidental findings, Bianchi recommends the field come together to standardize procedures and education.

The reference standards will support CareDx's solid organ transplant injury monitoring diagnostic tests and be integrated into CLIA laboratory testing. 

The firm will discontinue its SensiGene Fetal RHD test.

If CareDx successfully commercializes its cfDNA tests, they would be the firm's first products since AlloMap launched in 2005.

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According to New Scientist, GEDmatch changed its terms and conditions over the weekend to opt its users out of law enforcement searches.

A twin study uncovers evidence that genes may influence whether someone gets a dog, Martha Stewart reports.

The Atlantic looks into time spent pursuing gene leads generated through candidate gene studies.

In PNAS this week: Cdx2 cells can help regenerate heart tissue in mice following a heart attack, PIWI-interacting small RNA levels in human cancer, and more.