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cancer subtypes

Array-based gene expression data suggests luminal and basal subtypes present in both human and canine forms of invasive urothelial carcinoma.

With virtual microdissection, the team tracked down stromal and tumor subtypes related to pancreatic patient outcome.

Using a method that relied on Affymetrix arrays, researchers found that 38 patients in the trial had gene expression indicating they were in the ABC subtype.

Clinicians at the recent ASCO noted that more practical and accurate molecular diagnostics are approaching the clinic alongside novel targeted drug regimens.

Using TCGA and other data, two teams have identified subsets of glioma with distinct molecular markers, mutation patterns, and survival outcomes. 

Signifikance's platform is currently used for analyzing and interpreting cancer variants but will soon support prenatal screening and testing as well.

The firm will launch an onsite version of its clinical decision support system this year and expects to add tumor profiling services next year.

Researchers did genome sequencing and copy number testing on samples from 100 pancreatic ductal carcinoma patients, building on prior ICGC exome findings.

NEW YORK (GenomeWeb) — Data from the Neoadjuvant Breast Registry Symphony Trial, led by Pat Whitworth of the Nashville Breast Center and funded by Agendia, have confirmed earlier findings supporting Agendia's BluePrint molecular subtyping assay as a more effective predictor of adjuvant chemothera

NEW YORK (GenomeWeb) — An analysis of data from The Cancer Genome Atlas' comprehensive molecular profiling of squamous cell head and neck cancer has revealed a more complicated molecular landscape for the disease, and has identified a new genomic subset that indicates particularly poor survival.

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Researchers tie a variant in ADAMTS3 to breathing difficulties in dissimilar dog breeds, according to Discover's D-brief blog.

The Japan Times reports that researchers sequenced the genome of a woman who lived during the Jomon period.

Parents of children with rare genetic disease have to contend with shifts in the interpretation of genetic variants, the Wall Street Journal reports.

In Science this week: single-nucleus RNA sequencing of brain tissue from individuals with autism, and more.