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cancer subtypes

A genomic analysis of melanoma subtypes affecting the skin, mucosal tissues, and hands or feet found a range of mutations and structural changes.

Using point mutation and structural variant patterns in 133 ovarian cancer cases, researchers identified seven clusters to classify the disease and predict patient outcomes.

Shared gastric adenocarcinoma tumor features seem to span geography and ethnicity, despite shifts in the proportion of tumors from different molecular subtypes.

The new algorithm, called TOPSPIN, complements the company's MMprofiler test. It is considering making TOPSPIN-generated data available to its MMprofiler patients.

The new data supports the continued marketing of BioNTech's breast cancer subtyping assay as an alternative to IHC, and suggests added value for the test in assessing Ki-67 specifically.

The activity follows a recent financing round that has enabled OncoDNA to build out its sales team as it courts new clients.

Chemotherapy response appears to be more robust in triple-negative breast tumors with mutations decreasing BRCA1 or BRCA2 expression.

In lower-grade glioma tumors lacking three known biomarkers, investigators identified TP53 and H3.3 histone mutations that appear to be linked to poor outcomes.

By analyzing the transcriptomes of more than 4,000 individual cells, researchers identified stem cell-like cellular subpopulations in six oligodendroglioma tumors.

Data for hundreds of breast tumors suggested specific signatures were more closely linked to tumor-infiltrating lymphocyte activity than was mutational load. 

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Direct-to-consumer genetic testing firm 23andMe is laying off about 100 people.

Rady Children's Institute for Genomic Medicine and Deloitte are looking into the use of drones to transport samples for testing. 

Researchers from Northwestern University examined dust for antibiotic-resistance genes, New Scientist reports. 

In Science this week: researchers present a computational method for predicting cellular differentiation state from single-cell RNA sequencing data, and more.