cancer subtypes Breast Cancer Genomics Study Reveals Recurrent Contributors to Treatment Resistance in Early Disease Researchers saw convergent subclones crop up in early-stage, estrogen receptor-positive breast cancers that dodged endocrine- and CDK4/6 inhibitor-based therapies. Glioblastoma Omics Study Highlights Informative Tumor Features, Immune Subtypes Genomic, transcriptomic, proteomic, and post-transcriptional modification features in nearly 100 GBM tumors offered clues to tumor biology, revealing four immune subtypes. Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors. Neuroblastoma Super Enhancer Profiles Pinpoint Four Epigenetic Subtypes Using a combination of genomic and epigenomic profiling, researchers spelled out super enhancer-based subtypes, including one linked to poor clinical outcomes. Pediatric Brain Tumor Proteomics Highlight Possible Treatment Targets, Biomarkers An integrated proteogenomic analysis led to previously unappreciated treatment targets or prognostic markers in craniopharyngioma, high-grade glioma, and other tumor types. Oct 27, 2020 Clonal Hematopoiesis Mutation Study Reveals Risk of Treatment-Related Cancer Sep 17, 2020 Adrenal Neuroblastoma Cell Features Found by Single-Cell Transcriptome Sequencing Sep 4, 2020 Integrated Proteomic Study Leads to Metastasis, Response Clues in Chinese Colorectal Cancer Cases Aug 13, 2020 Triple-Negative Breast Cancer Treatment Hints Drawn From Single-Cell Study Jul 29, 2020 Pancreatic Cancer Action Network, GeneCentric Therapeutics Launch Research Partnership Jul 13, 2020 Metastatic Prostate Cancer Methylation Analysis Reveals Subtype, Ties to Driver Genes Jun 24, 2020 Stanford Team Debuts EPIC-Seq Method to Detect, Classify Cancer From cfDNA Fragment Patterns Jun 18, 2020 MMRF Taps GNS Healthcare to Analyze Multiple Myeloma Dataset Apr 3, 2020 Breast Cancer Subtypes Vary With Indigenous Ancestry in Latin American Women Dec 12, 2019 Proteomic Subtypes Identified in Pan-Cancer Analysis Nov 1, 2019 Breast Cancer Recurrence Risk Predicted by Immune-Related Germline Variants May 6, 2019 RB1 Alterations in Advanced Prostate Cancer Associated With Poor Outcome May 2, 2019 Immunotherapy Response in MMR-Deficient Tumors Linked to MSI Levels, Indel Mutations Apr 25, 2019 Colon Cancer Biology, Treatment Clues Found in Proteogenomic Analysis Apr 17, 2019 Non-Small Cell Lung Cancer Mutations, Tumor Microenvironment Profiled in China Apr 8, 2019 Proteome Analysis of Five Breast Tumor Subtypes Points to Additional Classifications Mar 29, 2019 Acute Erythroleukemia Genomic Subtypes Help Predict Outcomes, Suggest Therapies Mar 13, 2019 Breast Cancer Relapse Risk Predicted From Molecular Subtypes Mar 7, 2019 Triple-Negative Breast Cancer Mutations, Subtypes Profiled in Chinese Patients Jan 10, 2019 Potential Prognostic Signature Described in HPV-Positive Squamous Cell Carcinomas Load More Breaking News Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy Space Radiation Shows Limited Effects on Mammalian Sperm DNA, Fertility Bluestar Genomics Sues Former Consultant, Ludwig Institute for Cancer Research Over IP Ownership New Products Posted to GenomeWeb: 10x Genomics, Swift Biosciences, Agilent Technologies, More In Brief This Week: Quantum-Si, TGen, Yale, and More People in the News: New Appointments at Invitae, PGDx, Oxford Nanopore, PacBio, More The Scan Fertility Fraud Found Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today. Ties Between Vigorous Exercise, ALS in Genetically At-Risk People Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports. Test Warning The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK. Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.