Many molecularly distinct subgroups emerged from a meta-analysis bringing together more than 1,000 high-grade glioma or diffuse intrinsic pontine glioma cases.
The team found that cancer-causing genes depend on the BTK gene, which they believe they can shut down with an existing drug.
The Belgian company recently received €3.6 million to develop the signature into a clinical test within the next three years.
A new analysis hints that adenocarcinomas or squamous cell carcinomas may have certain overlapping expression patterns, regardless of the tissue of origin.
Researchers identified shifts in regulatory features and enhanced NOTCH signaling pathway activation in prostate tumors containing a TMPRSS2-ERG2 gene fusion.
Clustered mutation signatures in more than 1,000 tumors led to a process that appears to contribute to the development of some cancer driver mutations.
A recent JAMA Oncology study highlights the power of the open-access model GenomeDx has pursued since launching its Decipher prostate cancer prognostic.
Investigators identified new recurrently mutated genes and overlap with other histological endometrial cancer subtypes by profiling more than a dozen CCEC cases.
A genomic analysis of melanoma subtypes affecting the skin, mucosal tissues, and hands or feet found a range of mutations and structural changes.
Using point mutation and structural variant patterns in 133 ovarian cancer cases, researchers identified seven clusters to classify the disease and predict patient outcomes.
A research duo estimates in PLOS One the number of papers that have used misidentified cell lines.
UK's National Institute for Health and Care Excellence approves GlaxoSmithKline's SCID gene therapy despite cost.
Science reports that Brazilian researchers are petitioning for the reversal of budget cuts.
In PLOS this week: gene flow patterns in common ash, guidelines for using morpholinos in zebrafish, and more.