cancer subtypes | GenomeWeb

cancer subtypes

The activity follows a recent financing round that has enabled OncoDNA to build out its sales team as it courts new clients.

Chemotherapy response appears to be more robust in triple-negative breast tumors with mutations decreasing BRCA1 or BRCA2 expression.

In lower-grade glioma tumors lacking three known biomarkers, investigators identified TP53 and H3.3 histone mutations that appear to be linked to poor outcomes.

By analyzing the transcriptomes of more than 4,000 individual cells, researchers identified stem cell-like cellular subpopulations in six oligodendroglioma tumors.

Data for hundreds of breast tumors suggested specific signatures were more closely linked to tumor-infiltrating lymphocyte activity than was mutational load. 

The team has received around $900,000 in National Cancer Institute funding to develop new capabilities for CIVIC, improve curation, and engage with the community.

The new system emphasizes the importance of tumor biology as an important prognostic indicator for women who undergo neoadjuvant therapy, the researchers said.

Array-based gene expression data suggests luminal and basal subtypes present in both human and canine forms of invasive urothelial carcinoma.

With virtual microdissection, the team tracked down stromal and tumor subtypes related to pancreatic patient outcome.

Using a method that relied on Affymetrix arrays, researchers found that 38 patients in the trial had gene expression indicating they were in the ABC subtype.

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In PLOS this week: a sequencing-based screen of Lyme disease-causing pathogen, the range of animals bitten by Anopheles darling mosquitoes in Peru, and more.

An NC State researcher is exploring the use of CRISPR-Cas3 as an anti-microbial, Gizmodo reports.

The Earth BioGenome Project plans to sequence all life on Earth, according to ScienceInsider.

For those who are concerned about Trump administration actions related to science, a new column in Scientific American has suggestions for ways to fight back.